Fast T2*-weighted MRI of the prostate at 3 Tesla

Rulon L. Hardman, Fadi El-Merhi, Adam J. Jung, Steve Ware, Ian M. Thompson, Harry T. Friel, Qi Peng

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Purpose: To describe a rapid T2*-weighted (T2*W), three-dimensional (3D) echo planar imaging (EPI) sequence and its application in mapping local magnetic susceptibility variations in 3 Tesla (T) prostate MRI. To compare the sensitivity of T2*W EPI with routinely used T1-weighted turbo-spin echo sequence (T1W TSE) in detecting hemorrhage and the implications on sequences sensitive to field inhomogeneities such as MR spectroscopy (MRS). Materials and Methods: B0 susceptibility weighted mapping was performed using a 3D EPI sequence featuring a 2D spatial excitation pulse with gradients of spiral k-space trajectory. A series of 11 subjects were imaged using 3T MRI and combination endorectal (ER) and six-channel phased array cardiac coils. T1W TSE and T2*W EPI sequences were analyzed quantitatively for hemorrhage contrast. Point resolved spectroscopy (PRESS MRS) was performed and data quality was analyzed. Results: Two types of susceptibility variation were identified: hemorrhagic and nonhemorrhagic T2*W-positive areas. Post-biopsy hemorrhage lesions showed on average five times greater contrast on the T2*W images than T1W TSE images. Six nonhemorrhage regions of severe susceptibility artifact were apparent on the T2*W images that were not seen on standard T1W or T2W images. All non-hemorrhagic susceptibility artifact regions demonstrated compromised spectral quality on 3D MRS. Conclusion: The fast T2*W EPI sequence identifies hemorrhagic and nonhemorrhagic areas of susceptibility variation that may be helpful in prostate MRI planning at 3.0T.

Original languageEnglish (US)
Pages (from-to)902-907
Number of pages6
JournalJournal of Magnetic Resonance Imaging
Volume33
Issue number4
DOIs
StatePublished - Apr 2011
Externally publishedYes

Fingerprint

Echo-Planar Imaging
Prostate
Magnetic Resonance Spectroscopy
Hemorrhage
Artifacts
Spectrum Analysis
Biopsy

Keywords

  • Magnetic resonance spectroscopy
  • MRI
  • Prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Medicine(all)

Cite this

Hardman, R. L., El-Merhi, F., Jung, A. J., Ware, S., Thompson, I. M., Friel, H. T., & Peng, Q. (2011). Fast T2*-weighted MRI of the prostate at 3 Tesla. Journal of Magnetic Resonance Imaging, 33(4), 902-907. https://doi.org/10.1002/jmri.22496

Fast T2*-weighted MRI of the prostate at 3 Tesla. / Hardman, Rulon L.; El-Merhi, Fadi; Jung, Adam J.; Ware, Steve; Thompson, Ian M.; Friel, Harry T.; Peng, Qi.

In: Journal of Magnetic Resonance Imaging, Vol. 33, No. 4, 04.2011, p. 902-907.

Research output: Contribution to journalArticle

Hardman, RL, El-Merhi, F, Jung, AJ, Ware, S, Thompson, IM, Friel, HT & Peng, Q 2011, 'Fast T2*-weighted MRI of the prostate at 3 Tesla', Journal of Magnetic Resonance Imaging, vol. 33, no. 4, pp. 902-907. https://doi.org/10.1002/jmri.22496
Hardman RL, El-Merhi F, Jung AJ, Ware S, Thompson IM, Friel HT et al. Fast T2*-weighted MRI of the prostate at 3 Tesla. Journal of Magnetic Resonance Imaging. 2011 Apr;33(4):902-907. https://doi.org/10.1002/jmri.22496
Hardman, Rulon L. ; El-Merhi, Fadi ; Jung, Adam J. ; Ware, Steve ; Thompson, Ian M. ; Friel, Harry T. ; Peng, Qi. / Fast T2*-weighted MRI of the prostate at 3 Tesla. In: Journal of Magnetic Resonance Imaging. 2011 ; Vol. 33, No. 4. pp. 902-907.
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