Fast reductive ligation of S-nitrosothiols

Hua Wang, Ming Xian

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

(Chemical Equation Presented) "Nitroso" knows: A process has been developed which converts unstable S-nitrosothiols into stable sulfenamide analogues (see scheme).Reductive ligation proceeds rapidly in mixed organic solvent/water systems to give high yields. By applying this reaction, an efficient strategy for detecting S-nitrosylation in proteins and other biological systems is envisioned.

Original languageEnglish (US)
Pages (from-to)6598-6601
Number of pages4
JournalAngewandte Chemie - International Edition
Volume47
Issue number35
DOIs
StatePublished - Aug 18 2008
Externally publishedYes

Fingerprint

S-Nitrosothiols
Biological systems
Organic solvents
Ligation
Proteins
Water
sulfenamide

Keywords

  • Nitrenes
  • Nitrogen oxides
  • Reductive ligation
  • S-nitrosothiols

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Fast reductive ligation of S-nitrosothiols. / Wang, Hua; Xian, Ming.

In: Angewandte Chemie - International Edition, Vol. 47, No. 35, 18.08.2008, p. 6598-6601.

Research output: Contribution to journalArticle

Wang, Hua ; Xian, Ming. / Fast reductive ligation of S-nitrosothiols. In: Angewandte Chemie - International Edition. 2008 ; Vol. 47, No. 35. pp. 6598-6601.
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