TY - JOUR
T1 - Family aggregation of upper airway soft tissue structures in normal subjects and patients with sleep apnea
AU - Schwab, Richard J.
AU - Pasirstein, Michael
AU - Kaplan, Laura
AU - Pierson, Robert
AU - Mackley, Adonna
AU - Hachadoorian, Robert
AU - Arens, Raanan
AU - Maislin, Greg
AU - Pack, Allan I.
PY - 2006/2/15
Y1 - 2006/2/15
N2 - Rationale: Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation. Objectives: We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea. Methods: We examined 55 sleep apnea probands (apnea-hypopnea index [AHI]: 43.2 ± 26.3 events/h), 55 proband siblings (AHI: 11.8 ± 16.6 events/h), 55 control subjects (AHI: 2.1 ± 1.7 events/h), and 55 control siblings (AHI: 4.2 ± 4.0 events/h). The study design used exact matching on ethnicity and sex, frequency matching on age, and statistical control for visceral neck fat and craniofacial dimensions. Measurements and Main Results: The data support our a priori hypothesis that the volume of the important upper airway soft tissue structures is heritable. The volume of the lateral pharyngeal walls (h2 = 36.8%; p = 0.001), tongue (h2 = 36.5%; p = 0.0001), and total soft tissue (h2 = 37.5%; p = 0.0001) demonstrated significant levels of heritability after adjusting for sex, ethnicity, age, visceral neck fat, and craniofacial dimensions. In addition, our data indicate that heritability of the upper airway soft tissue structures is found in normal subjects and patients with apnea. Thus, it is not simply a consequence of the prevalence of apnea. Conclusions: This is the first time family aggregation of size of the upper airway soft tissue structures has been demonstrated.
AB - Rationale: Sleep apnea is believed to be a genetic disorder. Thus, we hypothesized that anatomic risk factors for sleep apnea would demonstrate family aggregation. Objectives: We used volumetric magnetic resonance imaging in a sib pair "quad" design to study the family aggregation of the size of upper airway soft tissue structures that are associated with increased risk for obstructive sleep apnea. Methods: We examined 55 sleep apnea probands (apnea-hypopnea index [AHI]: 43.2 ± 26.3 events/h), 55 proband siblings (AHI: 11.8 ± 16.6 events/h), 55 control subjects (AHI: 2.1 ± 1.7 events/h), and 55 control siblings (AHI: 4.2 ± 4.0 events/h). The study design used exact matching on ethnicity and sex, frequency matching on age, and statistical control for visceral neck fat and craniofacial dimensions. Measurements and Main Results: The data support our a priori hypothesis that the volume of the important upper airway soft tissue structures is heritable. The volume of the lateral pharyngeal walls (h2 = 36.8%; p = 0.001), tongue (h2 = 36.5%; p = 0.0001), and total soft tissue (h2 = 37.5%; p = 0.0001) demonstrated significant levels of heritability after adjusting for sex, ethnicity, age, visceral neck fat, and craniofacial dimensions. In addition, our data indicate that heritability of the upper airway soft tissue structures is found in normal subjects and patients with apnea. Thus, it is not simply a consequence of the prevalence of apnea. Conclusions: This is the first time family aggregation of size of the upper airway soft tissue structures has been demonstrated.
KW - Family aggregation
KW - Genetics
KW - Magnetic resonance imaging
KW - Obstructive sleep apnea
KW - Upper airway
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U2 - 10.1164/rccm.200412-1736OC
DO - 10.1164/rccm.200412-1736OC
M3 - Article
C2 - 16210668
AN - SCOPUS:32444432176
SN - 1073-449X
VL - 173
SP - 453
EP - 463
JO - American journal of respiratory and critical care medicine
JF - American journal of respiratory and critical care medicine
IS - 4
ER -