Familial transitional cell carcinoma among the population of Iceland

Lambertus A. Kiemeney, N. Charlotte Moret, J. Alfred Witjes, Mark P. Schoenberg, Hrafn Tulinius

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: Several case reports have described familial aggregation of transitional cell carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer. We evaluated the extent of familial aggregation of transitional cell carcinoma among the population of Iceland. Materials and Methods: The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis transitional cell carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource. The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry. The observed occurrence of transitional cell carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates. Observed-to-expected ratios and 95% confidence intervals were calculated. Results: In 41 of the 190 pedigrees at least 1 relative had transitional cell carcinoma of the urinary tract. Of the probands 38 had only 1 and 3 had 2 affected relatives. The prevalence of family history of transitional cell carcinoma was 3% in first degree and 10% in first or second degree relatives. The risk of transitional cell carcinoma among all relatives was slightly elevated (observed-to-expected ratio 1.24, 95% confidence interval 0.90 to 1.67). The observed-to-expected ratio was greater among second and third degree relatives than among first degree relatives. Conclusions: The risk of transitional cell carcinoma among relatives of patients is somewhat increased. However, the greater risk for more distant relatives argues against the existence of a hereditary subtype of bladder transitional cell carcinoma, at least in the founder population of Iceland.

Original languageEnglish (US)
Pages (from-to)1649-1651
Number of pages3
JournalJournal of Urology
Volume157
Issue number5
DOIs
StatePublished - May 1997
Externally publishedYes

Fingerprint

Iceland
Transitional Cell Carcinoma
Population
Urinary Tract
Urinary Bladder
Confidence Intervals
Kidney Pelvis
Pedigree
Ureter
Urinary Bladder Neoplasms
Registries
Epidemiologic Studies
Neoplasms

Keywords

  • bladder neoplasms
  • carcinoma, transitional cell
  • family

ASJC Scopus subject areas

  • Urology

Cite this

Familial transitional cell carcinoma among the population of Iceland. / Kiemeney, Lambertus A.; Moret, N. Charlotte; Witjes, J. Alfred; Schoenberg, Mark P.; Tulinius, Hrafn.

In: Journal of Urology, Vol. 157, No. 5, 05.1997, p. 1649-1651.

Research output: Contribution to journalArticle

Kiemeney, Lambertus A. ; Moret, N. Charlotte ; Witjes, J. Alfred ; Schoenberg, Mark P. ; Tulinius, Hrafn. / Familial transitional cell carcinoma among the population of Iceland. In: Journal of Urology. 1997 ; Vol. 157, No. 5. pp. 1649-1651.
@article{eaf1dfc2a15341da99edc2a52461409b,
title = "Familial transitional cell carcinoma among the population of Iceland",
abstract = "Purpose: Several case reports have described familial aggregation of transitional cell carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer. We evaluated the extent of familial aggregation of transitional cell carcinoma among the population of Iceland. Materials and Methods: The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis transitional cell carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource. The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry. The observed occurrence of transitional cell carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates. Observed-to-expected ratios and 95{\%} confidence intervals were calculated. Results: In 41 of the 190 pedigrees at least 1 relative had transitional cell carcinoma of the urinary tract. Of the probands 38 had only 1 and 3 had 2 affected relatives. The prevalence of family history of transitional cell carcinoma was 3{\%} in first degree and 10{\%} in first or second degree relatives. The risk of transitional cell carcinoma among all relatives was slightly elevated (observed-to-expected ratio 1.24, 95{\%} confidence interval 0.90 to 1.67). The observed-to-expected ratio was greater among second and third degree relatives than among first degree relatives. Conclusions: The risk of transitional cell carcinoma among relatives of patients is somewhat increased. However, the greater risk for more distant relatives argues against the existence of a hereditary subtype of bladder transitional cell carcinoma, at least in the founder population of Iceland.",
keywords = "bladder neoplasms, carcinoma, transitional cell, family",
author = "Kiemeney, {Lambertus A.} and Moret, {N. Charlotte} and Witjes, {J. Alfred} and Schoenberg, {Mark P.} and Hrafn Tulinius",
year = "1997",
month = "5",
doi = "10.1016/S0022-5347(01)64821-3",
language = "English (US)",
volume = "157",
pages = "1649--1651",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "5",

}

TY - JOUR

T1 - Familial transitional cell carcinoma among the population of Iceland

AU - Kiemeney, Lambertus A.

AU - Moret, N. Charlotte

AU - Witjes, J. Alfred

AU - Schoenberg, Mark P.

AU - Tulinius, Hrafn

PY - 1997/5

Y1 - 1997/5

N2 - Purpose: Several case reports have described familial aggregation of transitional cell carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer. We evaluated the extent of familial aggregation of transitional cell carcinoma among the population of Iceland. Materials and Methods: The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis transitional cell carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource. The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry. The observed occurrence of transitional cell carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates. Observed-to-expected ratios and 95% confidence intervals were calculated. Results: In 41 of the 190 pedigrees at least 1 relative had transitional cell carcinoma of the urinary tract. Of the probands 38 had only 1 and 3 had 2 affected relatives. The prevalence of family history of transitional cell carcinoma was 3% in first degree and 10% in first or second degree relatives. The risk of transitional cell carcinoma among all relatives was slightly elevated (observed-to-expected ratio 1.24, 95% confidence interval 0.90 to 1.67). The observed-to-expected ratio was greater among second and third degree relatives than among first degree relatives. Conclusions: The risk of transitional cell carcinoma among relatives of patients is somewhat increased. However, the greater risk for more distant relatives argues against the existence of a hereditary subtype of bladder transitional cell carcinoma, at least in the founder population of Iceland.

AB - Purpose: Several case reports have described familial aggregation of transitional cell carcinoma of the urinary tract but to our knowledge only 1 epidemiological study specifically addressed the issue of familial bladder cancer. We evaluated the extent of familial aggregation of transitional cell carcinoma among the population of Iceland. Materials and Methods: The first to third degree relatives of 190 patients with bladder, ureter or renal pelvis transitional cell carcinoma diagnosed between 1983 and 1992 in Iceland were identified through the Icelandic Cancer Family Resource. The records of these 12,328 relatives were subsequently linked to the 1965 to 1994 cancer registry. The observed occurrence of transitional cell carcinoma of the urinary tract was compared to the expected occurrence based on age, gender and calendar specific incidence rates. Observed-to-expected ratios and 95% confidence intervals were calculated. Results: In 41 of the 190 pedigrees at least 1 relative had transitional cell carcinoma of the urinary tract. Of the probands 38 had only 1 and 3 had 2 affected relatives. The prevalence of family history of transitional cell carcinoma was 3% in first degree and 10% in first or second degree relatives. The risk of transitional cell carcinoma among all relatives was slightly elevated (observed-to-expected ratio 1.24, 95% confidence interval 0.90 to 1.67). The observed-to-expected ratio was greater among second and third degree relatives than among first degree relatives. Conclusions: The risk of transitional cell carcinoma among relatives of patients is somewhat increased. However, the greater risk for more distant relatives argues against the existence of a hereditary subtype of bladder transitional cell carcinoma, at least in the founder population of Iceland.

KW - bladder neoplasms

KW - carcinoma, transitional cell

KW - family

UR - http://www.scopus.com/inward/record.url?scp=0030897075&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030897075&partnerID=8YFLogxK

U2 - 10.1016/S0022-5347(01)64821-3

DO - 10.1016/S0022-5347(01)64821-3

M3 - Article

VL - 157

SP - 1649

EP - 1651

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 5

ER -