Familial Hypocalciuric Hypocalcemia

David B. Calandra, Edward Paloyan, A. M. Lawrence, Walter T. Goar, Stephen Marx, Allen Spiegel, Roz Lasker, Arthur Santora, Robert Downs, Gerald Aurbach

Research output: Contribution to journalLetter

3 Scopus citations


To the Editor: We write out of serious concern for what we believe is an inappropriate recommendation of Marx et al. (August 12 issue)* that familial hypercalcemia with hypocalciuria, relative to urinary calcium levels in a majority of patients with hyperparathyroidism, essentially remain untreated. Admittedly, some controversy continues over whether this syndrome is legitimately any different from primary hyperparathyroidism presenting in a familial form. An autosomally dominant mode of transmission of hypercalcemia, inappropriately raised parathyroid hormone levels for a given degree of hypercalcemia, increased urinary cyclic AMP, and the induction of hypocalcemia after adequate removal of hyperplastic parathyroid tissue are.

Original languageEnglish (US)
Pages (from-to)48-49
Number of pages2
JournalNew England Journal of Medicine
Issue number1
StatePublished - Jan 6 1983
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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    Calandra, D. B., Paloyan, E., Lawrence, A. M., Goar, W. T., Marx, S., Spiegel, A., Lasker, R., Santora, A., Downs, R., & Aurbach, G. (1983). Familial Hypocalciuric Hypocalcemia. New England Journal of Medicine, 308(1), 48-49. https://doi.org/10.1056/NEJM198301063080115