Failure of neuronal maturation in Alzheimer disease dentate gyrus

Bin Li, Hidenaga Yamamori, Yoshitaka Tatebayashi, Bridget Shafit-Zagardo, Hitoshi Tanimukai, She Chen, Khalid Iqbal, Inge Grundke-Iqbal

Research output: Contribution to journalArticle

159 Citations (Scopus)

Abstract

The dentate gyrus, an important anatomic structure of the hippocampal formation, is one of the major areas in which neurogenesis takes place in the adult mammalian brain. Neurogenesis in the dentate gyrus is thought to play an important role in hippocampus-dependent learning and memory. Neurogenesis has been reported to be increased in the dentate gyrus of patients with Alzheimer disease, but it is not known whether the newly generated neurons differentiate into mature neurons. In this study, the expression of the mature neuronal marker high molecular weight microtubule-associated protein (MAP) isoforms MAP2a and b was found to be dramatically decreased in Alzheimer disease dentate gyrus, as determined by immunohistochemistry and in situ hybridization. The total MAP2, including expression of the immature neuronal marker, the MAP2c isoform, was less affected. These findings suggest that newly generated neurons in Alzheimer disease dentate gyrus do not become mature neurons, although neuroproliferation is increased.

Original languageEnglish (US)
Pages (from-to)78-84
Number of pages7
JournalJournal of Neuropathology and Experimental Neurology
Volume67
Issue number1
DOIs
StatePublished - Jan 2008

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Dentate Gyrus
Alzheimer Disease
Neurogenesis
Neurons
Hippocampus
Protein Isoforms
Microtubule-Associated Proteins
In Situ Hybridization
Molecular Weight
Immunohistochemistry
Learning
Brain

Keywords

  • Alzheimer disease
  • Hippocampus
  • Microtubuleassociated protein 2
  • Neurogenesis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Neuroscience(all)

Cite this

Failure of neuronal maturation in Alzheimer disease dentate gyrus. / Li, Bin; Yamamori, Hidenaga; Tatebayashi, Yoshitaka; Shafit-Zagardo, Bridget; Tanimukai, Hitoshi; Chen, She; Iqbal, Khalid; Grundke-Iqbal, Inge.

In: Journal of Neuropathology and Experimental Neurology, Vol. 67, No. 1, 01.2008, p. 78-84.

Research output: Contribution to journalArticle

Li, B, Yamamori, H, Tatebayashi, Y, Shafit-Zagardo, B, Tanimukai, H, Chen, S, Iqbal, K & Grundke-Iqbal, I 2008, 'Failure of neuronal maturation in Alzheimer disease dentate gyrus', Journal of Neuropathology and Experimental Neurology, vol. 67, no. 1, pp. 78-84. https://doi.org/10.1097/nen.0b013e318160c5db
Li, Bin ; Yamamori, Hidenaga ; Tatebayashi, Yoshitaka ; Shafit-Zagardo, Bridget ; Tanimukai, Hitoshi ; Chen, She ; Iqbal, Khalid ; Grundke-Iqbal, Inge. / Failure of neuronal maturation in Alzheimer disease dentate gyrus. In: Journal of Neuropathology and Experimental Neurology. 2008 ; Vol. 67, No. 1. pp. 78-84.
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