TY - JOUR
T1 - Failure of effective initial chemotherapy to modify the course of stage IV (MO) squamous cancer of the head and neck
AU - Vogl, Steven E.
AU - Lerner, Harvey
AU - Kaplan, Barry H.
AU - Coughlin, Christopher
AU - McCormick, Beryl
AU - Camacho, Fernando
AU - Cinberg, James
PY - 1982/9/1
Y1 - 1982/9/1
N2 - Twenty‐four patients with advanced squamous cancer of the head and neck without distant metastases were given combination chemotherapy including methotrexate, bleomycin and diamminedichloroplatinum before planned local treatment with irradiation or surgery. Of 22 evaluable patients, 17 had objective partial or complete remission to initial chemotherapy. However, only ten patients ever had complete clearing at any time of all tumor on clinical evaluation. Median survival was ten months, and only two patients remained alive 14 and 29 months, respectively, from entry. Toxicity was minimal with the three‐drug treatment, but the addition of mitomycin‐C at the start of chemotherapy substantially increased toxicity without improving efficacy. Subsequent surgery and radiotherapy were accomplished without unusual difficulty.
AB - Twenty‐four patients with advanced squamous cancer of the head and neck without distant metastases were given combination chemotherapy including methotrexate, bleomycin and diamminedichloroplatinum before planned local treatment with irradiation or surgery. Of 22 evaluable patients, 17 had objective partial or complete remission to initial chemotherapy. However, only ten patients ever had complete clearing at any time of all tumor on clinical evaluation. Median survival was ten months, and only two patients remained alive 14 and 29 months, respectively, from entry. Toxicity was minimal with the three‐drug treatment, but the addition of mitomycin‐C at the start of chemotherapy substantially increased toxicity without improving efficacy. Subsequent surgery and radiotherapy were accomplished without unusual difficulty.
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U2 - 10.1002/1097-0142(19820901)50:5<840::AID-CNCR2820500506>3.0.CO;2-9
DO - 10.1002/1097-0142(19820901)50:5<840::AID-CNCR2820500506>3.0.CO;2-9
M3 - Article
C2 - 6178496
AN - SCOPUS:0019959510
SN - 0008-543X
VL - 50
SP - 840
EP - 844
JO - Cancer
JF - Cancer
IS - 5
ER -