Failed methotrexate termination of pregnancy

A case report

D. Goffman, D. S. Cole, P. Bobby, D. J. Garry

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

We report a case of a fetus with shortened proximal long bones, ambiguous genitalia, intrauterine growth restriction and abnormal umbilical artery Doppler velocities observed on antenatal ultrasound exam. At 34 weeks the patient revealed methotrexate/misoprostol exposure at 6 weeks gestational age in attempted medical termination of pregnancy. On newborn exam, the baby had dysmorphic facial features, a short torso, scoliosis, a micropenis (phallus <1cm) and shortened proximal long bones both upper and lower extremities. X-ray exam revealed a hemivertebra at T10 level, rib abnormalities, shortened proximal long bones, an absent pubic bone and bilateral knee ossification centers. With methotrexate exposure, improved counseling and surveillance could potentially avoid these significant abnormalities and prevent psychological distress.

Original languageEnglish (US)
Pages (from-to)645-647
Number of pages3
JournalJournal of Perinatology
Volume26
Issue number10
DOIs
StatePublished - Oct 2006

Fingerprint

Methotrexate
Bones of Lower Extremity
Pubic Bone
Bone and Bones
Disorders of Sex Development
Torso
Misoprostol
Pregnancy
Umbilical Arteries
Scoliosis
Ribs
Osteogenesis
Upper Extremity
Gestational Age
Counseling
Knee
Fetus
X-Rays
Newborn Infant
Psychology

ASJC Scopus subject areas

  • Obstetrics and Gynecology
  • Pediatrics, Perinatology, and Child Health

Cite this

Goffman, D., Cole, D. S., Bobby, P., & Garry, D. J. (2006). Failed methotrexate termination of pregnancy: A case report. Journal of Perinatology, 26(10), 645-647. https://doi.org/10.1038/sj.jp.7211563

Failed methotrexate termination of pregnancy : A case report. / Goffman, D.; Cole, D. S.; Bobby, P.; Garry, D. J.

In: Journal of Perinatology, Vol. 26, No. 10, 10.2006, p. 645-647.

Research output: Contribution to journalArticle

Goffman, D, Cole, DS, Bobby, P & Garry, DJ 2006, 'Failed methotrexate termination of pregnancy: A case report', Journal of Perinatology, vol. 26, no. 10, pp. 645-647. https://doi.org/10.1038/sj.jp.7211563
Goffman, D. ; Cole, D. S. ; Bobby, P. ; Garry, D. J. / Failed methotrexate termination of pregnancy : A case report. In: Journal of Perinatology. 2006 ; Vol. 26, No. 10. pp. 645-647.
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