Abstract
We report a case of a fetus with shortened proximal long bones, ambiguous genitalia, intrauterine growth restriction and abnormal umbilical artery Doppler velocities observed on antenatal ultrasound exam. At 34 weeks the patient revealed methotrexate/misoprostol exposure at 6 weeks gestational age in attempted medical termination of pregnancy. On newborn exam, the baby had dysmorphic facial features, a short torso, scoliosis, a micropenis (phallus <1cm) and shortened proximal long bones both upper and lower extremities. X-ray exam revealed a hemivertebra at T10 level, rib abnormalities, shortened proximal long bones, an absent pubic bone and bilateral knee ossification centers. With methotrexate exposure, improved counseling and surveillance could potentially avoid these significant abnormalities and prevent psychological distress.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 645-647 |
| Number of pages | 3 |
| Journal | Journal of Perinatology |
| Volume | 26 |
| Issue number | 10 |
| DOIs | |
| State | Published - Oct 2006 |
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ASJC Scopus subject areas
- Obstetrics and Gynecology
- Pediatrics, Perinatology, and Child Health
Cite this
Failed methotrexate termination of pregnancy : A case report. / Goffman, D.; Cole, D. S.; Bobby, P.; Garry, D. J.
In: Journal of Perinatology, Vol. 26, No. 10, 10.2006, p. 645-647.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Failed methotrexate termination of pregnancy
T2 - A case report
AU - Goffman, D.
AU - Cole, D. S.
AU - Bobby, P.
AU - Garry, D. J.
PY - 2006/10
Y1 - 2006/10
N2 - We report a case of a fetus with shortened proximal long bones, ambiguous genitalia, intrauterine growth restriction and abnormal umbilical artery Doppler velocities observed on antenatal ultrasound exam. At 34 weeks the patient revealed methotrexate/misoprostol exposure at 6 weeks gestational age in attempted medical termination of pregnancy. On newborn exam, the baby had dysmorphic facial features, a short torso, scoliosis, a micropenis (phallus <1cm) and shortened proximal long bones both upper and lower extremities. X-ray exam revealed a hemivertebra at T10 level, rib abnormalities, shortened proximal long bones, an absent pubic bone and bilateral knee ossification centers. With methotrexate exposure, improved counseling and surveillance could potentially avoid these significant abnormalities and prevent psychological distress.
AB - We report a case of a fetus with shortened proximal long bones, ambiguous genitalia, intrauterine growth restriction and abnormal umbilical artery Doppler velocities observed on antenatal ultrasound exam. At 34 weeks the patient revealed methotrexate/misoprostol exposure at 6 weeks gestational age in attempted medical termination of pregnancy. On newborn exam, the baby had dysmorphic facial features, a short torso, scoliosis, a micropenis (phallus <1cm) and shortened proximal long bones both upper and lower extremities. X-ray exam revealed a hemivertebra at T10 level, rib abnormalities, shortened proximal long bones, an absent pubic bone and bilateral knee ossification centers. With methotrexate exposure, improved counseling and surveillance could potentially avoid these significant abnormalities and prevent psychological distress.
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UR - http://www.scopus.com/inward/citedby.url?scp=33749370860&partnerID=8YFLogxK
U2 - 10.1038/sj.jp.7211563
DO - 10.1038/sj.jp.7211563
M3 - Article
C2 - 17006526
AN - SCOPUS:33749370860
VL - 26
SP - 645
EP - 647
JO - Journal of Perinatology
JF - Journal of Perinatology
SN - 0743-8346
IS - 10
ER -