Factors associated with willingness to participate in a vaccine clinical trial among elderly Hispanic patients

Sharon Rikin, Steven Shea, Philip LaRussa, Melissa Stockwell

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A population specific understanding of barriers and facilitators to participation in clinical trials could improve recruitment of elderly and minority populations. We investigated how prior exposure to clinical trials and incentives were associated with likelihood of participation in a vaccine clinical trial through a questionnaire administered to 200 elderly patients in an academic general internal medicine clinic. Wilcoxon signed rank sum test compared likelihood of participation with and without monetary incentives. Logistic regression evaluated characteristics associated with intent to participate in an influenza vaccine trial, adjusted for age, gender, language, and education history. When asked about likelihood of participation if there was monetary compensation, there was a 12.2% absolute increase in those reporting that they would not participate, with a significant difference in the distribution of likelihood before and after mentioning a monetary incentive (Wilcoxon signed rank test, p = 0.001). Those with previous knowledge of clinical trials (54.4%) were more likely to report they would participate vs. those without prior knowledge (OR 2.5, 95% CI [1.2, 5.2]). The study highlights the importance of pre-testing recruitment materials and incentives in key group populations prior to implementing clinical trials.

Original languageEnglish (US)
Pages (from-to)122-125
Number of pages4
JournalContemporary Clinical Trials Communications
Volume7
DOIs
StatePublished - Sep 1 2017
Externally publishedYes

Fingerprint

Hispanic Americans
Vaccines
Clinical Trials
Motivation
Nonparametric Statistics
Materials Testing
Influenza Vaccines
Internal Medicine
Population Groups
Population
Language
Logistic Models
History
Education

Keywords

  • Clinical trials
  • Disparities
  • Geriatrics
  • Research design

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology

Cite this

Factors associated with willingness to participate in a vaccine clinical trial among elderly Hispanic patients. / Rikin, Sharon; Shea, Steven; LaRussa, Philip; Stockwell, Melissa.

In: Contemporary Clinical Trials Communications, Vol. 7, 01.09.2017, p. 122-125.

Research output: Contribution to journalArticle

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