Factors associated with serum brain natriuretic peptide levels after the fontan procedure

Andrew M. Atz, Victor Zak, Roger E. Breitbart, Steven D. Colan, Sara K. Pasquali, Daphne T. Hsu, Minmin Lu, Lynn Mahony, Stephen M. Paridon, Michael D. Puchalski, Tal Geva, Brian W. McCrindle

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Objective. Although a useful marker of heart failure in adults, the utility of brain natriuretic peptide concentration (BNP) for children after the Fontan procedure is not well studied. Design. BNP was measured in 510 patients who were 6-18 years old in the Pediatric Heart Network Fontan cross-sectional study at a median of 8.2 years after Fontan. Patients underwent echocardiography, exercise testing, magnetic resonance imaging (MRI) and functional health status questionnaires. Associations of BNP with baseline patient characteristics, medical history and cross-sectional assessment were examined with multivariable linear regression analyses. Results. The distribution of BNP was highly skewed, median 13.0pg/mL (interquartile range: 7.1, 25.9), and was normalized with logarithmic transformation (logBNP). Among medical history variables, logBNP was greater in females (P= .02) and older patients (P < .001). Presence of pre-Fontan systolic ventricular dysfunction, greater number of post-Fontan complications, and thrombosis after Fontan were independently associated with higher logBNP (R 2= 0.16). Age-adjusted logBNP was significantly related to Fontan connection type (lower with extracardiac conduits, higher with atriopulmonary connection; P < .001). Lower physical functioning health status (R 2= 0.05), lower chronotropic index during exercise (R 2= 0.17), indices of diastolic dysfunction measured by echocardiography (R 2= 0.15), and higher total ventricular mass on MRI (R 2= 0.33) were related to higher logBNP. Conclusions. Despite a markedly abnormal circulation, BNP was variable but within a normal range in the majority of Fontan patients in this large outpatient cohort. Higher BNP was associated with several markers of suboptimal outcome, although associations were weak. The routine use of BNP as an outpatient surveillance tool in asymptomatic Fontan patients is not warranted.

Original languageEnglish (US)
Pages (from-to)313-321
Number of pages9
JournalCongenital Heart Disease
Volume6
Issue number4
DOIs
StatePublished - Jul 2011
Externally publishedYes

Fingerprint

Fontan Procedure
Brain Natriuretic Peptide
Serum
Health Status
Echocardiography
Outpatients
Magnetic Resonance Imaging
Exercise
Ventricular Dysfunction
Linear Models
Reference Values
Thrombosis
Heart Failure
Cross-Sectional Studies
Regression Analysis
Pediatrics

Keywords

  • Congenital heart defects
  • Fontan procedure
  • Natriuretic peptides

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Radiology Nuclear Medicine and imaging

Cite this

Atz, A. M., Zak, V., Breitbart, R. E., Colan, S. D., Pasquali, S. K., Hsu, D. T., ... McCrindle, B. W. (2011). Factors associated with serum brain natriuretic peptide levels after the fontan procedure. Congenital Heart Disease, 6(4), 313-321. https://doi.org/10.1111/j.1747-0803.2011.00496.x

Factors associated with serum brain natriuretic peptide levels after the fontan procedure. / Atz, Andrew M.; Zak, Victor; Breitbart, Roger E.; Colan, Steven D.; Pasquali, Sara K.; Hsu, Daphne T.; Lu, Minmin; Mahony, Lynn; Paridon, Stephen M.; Puchalski, Michael D.; Geva, Tal; McCrindle, Brian W.

In: Congenital Heart Disease, Vol. 6, No. 4, 07.2011, p. 313-321.

Research output: Contribution to journalArticle

Atz, AM, Zak, V, Breitbart, RE, Colan, SD, Pasquali, SK, Hsu, DT, Lu, M, Mahony, L, Paridon, SM, Puchalski, MD, Geva, T & McCrindle, BW 2011, 'Factors associated with serum brain natriuretic peptide levels after the fontan procedure', Congenital Heart Disease, vol. 6, no. 4, pp. 313-321. https://doi.org/10.1111/j.1747-0803.2011.00496.x
Atz, Andrew M. ; Zak, Victor ; Breitbart, Roger E. ; Colan, Steven D. ; Pasquali, Sara K. ; Hsu, Daphne T. ; Lu, Minmin ; Mahony, Lynn ; Paridon, Stephen M. ; Puchalski, Michael D. ; Geva, Tal ; McCrindle, Brian W. / Factors associated with serum brain natriuretic peptide levels after the fontan procedure. In: Congenital Heart Disease. 2011 ; Vol. 6, No. 4. pp. 313-321.
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abstract = "Objective. Although a useful marker of heart failure in adults, the utility of brain natriuretic peptide concentration (BNP) for children after the Fontan procedure is not well studied. Design. BNP was measured in 510 patients who were 6-18 years old in the Pediatric Heart Network Fontan cross-sectional study at a median of 8.2 years after Fontan. Patients underwent echocardiography, exercise testing, magnetic resonance imaging (MRI) and functional health status questionnaires. Associations of BNP with baseline patient characteristics, medical history and cross-sectional assessment were examined with multivariable linear regression analyses. Results. The distribution of BNP was highly skewed, median 13.0pg/mL (interquartile range: 7.1, 25.9), and was normalized with logarithmic transformation (logBNP). Among medical history variables, logBNP was greater in females (P= .02) and older patients (P < .001). Presence of pre-Fontan systolic ventricular dysfunction, greater number of post-Fontan complications, and thrombosis after Fontan were independently associated with higher logBNP (R 2= 0.16). Age-adjusted logBNP was significantly related to Fontan connection type (lower with extracardiac conduits, higher with atriopulmonary connection; P < .001). Lower physical functioning health status (R 2= 0.05), lower chronotropic index during exercise (R 2= 0.17), indices of diastolic dysfunction measured by echocardiography (R 2= 0.15), and higher total ventricular mass on MRI (R 2= 0.33) were related to higher logBNP. Conclusions. Despite a markedly abnormal circulation, BNP was variable but within a normal range in the majority of Fontan patients in this large outpatient cohort. Higher BNP was associated with several markers of suboptimal outcome, although associations were weak. The routine use of BNP as an outpatient surveillance tool in asymptomatic Fontan patients is not warranted.",
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AU - Zak, Victor

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AU - Pasquali, Sara K.

AU - Hsu, Daphne T.

AU - Lu, Minmin

AU - Mahony, Lynn

AU - Paridon, Stephen M.

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AB - Objective. Although a useful marker of heart failure in adults, the utility of brain natriuretic peptide concentration (BNP) for children after the Fontan procedure is not well studied. Design. BNP was measured in 510 patients who were 6-18 years old in the Pediatric Heart Network Fontan cross-sectional study at a median of 8.2 years after Fontan. Patients underwent echocardiography, exercise testing, magnetic resonance imaging (MRI) and functional health status questionnaires. Associations of BNP with baseline patient characteristics, medical history and cross-sectional assessment were examined with multivariable linear regression analyses. Results. The distribution of BNP was highly skewed, median 13.0pg/mL (interquartile range: 7.1, 25.9), and was normalized with logarithmic transformation (logBNP). Among medical history variables, logBNP was greater in females (P= .02) and older patients (P < .001). Presence of pre-Fontan systolic ventricular dysfunction, greater number of post-Fontan complications, and thrombosis after Fontan were independently associated with higher logBNP (R 2= 0.16). Age-adjusted logBNP was significantly related to Fontan connection type (lower with extracardiac conduits, higher with atriopulmonary connection; P < .001). Lower physical functioning health status (R 2= 0.05), lower chronotropic index during exercise (R 2= 0.17), indices of diastolic dysfunction measured by echocardiography (R 2= 0.15), and higher total ventricular mass on MRI (R 2= 0.33) were related to higher logBNP. Conclusions. Despite a markedly abnormal circulation, BNP was variable but within a normal range in the majority of Fontan patients in this large outpatient cohort. Higher BNP was associated with several markers of suboptimal outcome, although associations were weak. The routine use of BNP as an outpatient surveillance tool in asymptomatic Fontan patients is not warranted.

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