Factors associated with relapse and survival in Wilms tumor: A multivariate analysis

Joshua N. Honeyman, Barrie S. Rich, Maureen P. McEvoy, Molly A. Knowles, Glenn Heller, Edward Riachy, Rachel Kobos, Neerav Shukla, Suzanne L. Wolden, Peter G. Steinherz, Michael P. La Quaglia

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose: Lymph node metastasis and anaplasia predict relapse-free survival in Wilms tumor. We performed a multivariate analysis of our institutional database to identify factors independently associated with relapse-free and overall survival. Methods: We retrospectively reviewed cases of confirmed Wilms tumor diagnosed between 1990 and 2010 and treated at our institution. The log-rank test was used to screen variables for consideration in the proportional hazards model. Results: A total of 95 patients were treated at our institution during the study period, with a median follow-up of 3.3 years. Factors correlated with overall survival in the univariate analysis were local disease, metastasis, tumor size, anaplasia, renal vein tumor thrombus, inferior vena cava tumor thrombus, lymph node positivity, and tumor rupture. On multivariate analysis, factors associated with increased risk of death were lymph node positivity and anaplasia. Factors correlated with probability of relapse in the univariate analysis were lymph node positivity, anaplasia, and female sex. All 3 of these factors were also independently significant on multivariate analysis. Conclusion: Lymph node involvement and anaplasia are significantly correlated with probability of relapse and overall survival, reemphasizing the strong recommendation to sample regional lymph nodes during Wilms tumor resection.

Original languageEnglish (US)
Pages (from-to)1228-1233
Number of pages6
JournalJournal of Pediatric Surgery
Volume47
Issue number6
DOIs
StatePublished - Jun 1 2012
Externally publishedYes

Fingerprint

Anaplasia
Wilms Tumor
Multivariate Analysis
Lymph Nodes
Recurrence
Survival
Neoplasms
Thrombosis
Neoplasm Metastasis
Renal Veins
Inferior Vena Cava
Proportional Hazards Models
Rupture
Databases

Keywords

  • Lymph node metastasis
  • Multivariate analysis
  • Nephroblastoma
  • Wilms tumor

ASJC Scopus subject areas

  • Surgery
  • Pediatrics, Perinatology, and Child Health

Cite this

Honeyman, J. N., Rich, B. S., McEvoy, M. P., Knowles, M. A., Heller, G., Riachy, E., ... La Quaglia, M. P. (2012). Factors associated with relapse and survival in Wilms tumor: A multivariate analysis. Journal of Pediatric Surgery, 47(6), 1228-1233. https://doi.org/10.1016/j.jpedsurg.2012.03.030

Factors associated with relapse and survival in Wilms tumor : A multivariate analysis. / Honeyman, Joshua N.; Rich, Barrie S.; McEvoy, Maureen P.; Knowles, Molly A.; Heller, Glenn; Riachy, Edward; Kobos, Rachel; Shukla, Neerav; Wolden, Suzanne L.; Steinherz, Peter G.; La Quaglia, Michael P.

In: Journal of Pediatric Surgery, Vol. 47, No. 6, 01.06.2012, p. 1228-1233.

Research output: Contribution to journalArticle

Honeyman, JN, Rich, BS, McEvoy, MP, Knowles, MA, Heller, G, Riachy, E, Kobos, R, Shukla, N, Wolden, SL, Steinherz, PG & La Quaglia, MP 2012, 'Factors associated with relapse and survival in Wilms tumor: A multivariate analysis', Journal of Pediatric Surgery, vol. 47, no. 6, pp. 1228-1233. https://doi.org/10.1016/j.jpedsurg.2012.03.030
Honeyman, Joshua N. ; Rich, Barrie S. ; McEvoy, Maureen P. ; Knowles, Molly A. ; Heller, Glenn ; Riachy, Edward ; Kobos, Rachel ; Shukla, Neerav ; Wolden, Suzanne L. ; Steinherz, Peter G. ; La Quaglia, Michael P. / Factors associated with relapse and survival in Wilms tumor : A multivariate analysis. In: Journal of Pediatric Surgery. 2012 ; Vol. 47, No. 6. pp. 1228-1233.
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