Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV

Jessica S. Merlin, Ashutosh Tamhane, Joanna L. Starrels, Stefan Kertesz, Michael Saag, Karen Cropsey

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Opioids are often prescribed for chronic pain, and opioid risks such as overdose and death are heightened when opioids are co-prescribed with other sedating medications. We investigated factors associated with chronic opioid prescription, alone and in combination with benzodiazepines and muscle relaxants, in a clinical cohort of individuals with HIV. We used multivariable logistic regression models to determine participant clinical and demographic characteristics that are associated with chronic prescription of opioids or chronic co-prescription of opioids with sedating medications. Among 1474 participants, chronic prescription of opioids occurred in 253 individuals (17.2 %), and chronic co-prescription occurred in 90 individuals (6.1 %). Age >50, public insurance as compared to private insurance, and symptoms of depression and anxiety were significantly associated with chronic opioid prescription and chronic co-prescription. Our findings raise concern that opioid prescription and co-prescription of sedating medications occurs disproportionately in patients for whom use is riskier.

Original languageEnglish (US)
Pages (from-to)687-698
Number of pages12
JournalAIDS and Behavior
Volume20
Issue number3
DOIs
StatePublished - Mar 1 2016

Fingerprint

Opioid Analgesics
Prescriptions
HIV
Insurance
Logistic Models
Benzodiazepines
Chronic Pain
Anxiety
Demography
Depression
Muscles

Keywords

  • Benzodiazepine
  • Chronic pain
  • HIV
  • Muscle relaxant
  • Opioid

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases
  • Social Psychology

Cite this

Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV. / Merlin, Jessica S.; Tamhane, Ashutosh; Starrels, Joanna L.; Kertesz, Stefan; Saag, Michael; Cropsey, Karen.

In: AIDS and Behavior, Vol. 20, No. 3, 01.03.2016, p. 687-698.

Research output: Contribution to journalArticle

Merlin, Jessica S. ; Tamhane, Ashutosh ; Starrels, Joanna L. ; Kertesz, Stefan ; Saag, Michael ; Cropsey, Karen. / Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV. In: AIDS and Behavior. 2016 ; Vol. 20, No. 3. pp. 687-698.
@article{b50c6f4ee0b947548b138705f440253d,
title = "Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV",
abstract = "Opioids are often prescribed for chronic pain, and opioid risks such as overdose and death are heightened when opioids are co-prescribed with other sedating medications. We investigated factors associated with chronic opioid prescription, alone and in combination with benzodiazepines and muscle relaxants, in a clinical cohort of individuals with HIV. We used multivariable logistic regression models to determine participant clinical and demographic characteristics that are associated with chronic prescription of opioids or chronic co-prescription of opioids with sedating medications. Among 1474 participants, chronic prescription of opioids occurred in 253 individuals (17.2 {\%}), and chronic co-prescription occurred in 90 individuals (6.1 {\%}). Age >50, public insurance as compared to private insurance, and symptoms of depression and anxiety were significantly associated with chronic opioid prescription and chronic co-prescription. Our findings raise concern that opioid prescription and co-prescription of sedating medications occurs disproportionately in patients for whom use is riskier.",
keywords = "Benzodiazepine, Chronic pain, HIV, Muscle relaxant, Opioid",
author = "Merlin, {Jessica S.} and Ashutosh Tamhane and Starrels, {Joanna L.} and Stefan Kertesz and Michael Saag and Karen Cropsey",
year = "2016",
month = "3",
day = "1",
doi = "10.1007/s10461-015-1178-8",
language = "English (US)",
volume = "20",
pages = "687--698",
journal = "AIDS and Behavior",
issn = "1090-7165",
publisher = "Springer New York",
number = "3",

}

TY - JOUR

T1 - Factors Associated with Prescription of Opioids and Co-prescription of Sedating Medications in Individuals with HIV

AU - Merlin, Jessica S.

AU - Tamhane, Ashutosh

AU - Starrels, Joanna L.

AU - Kertesz, Stefan

AU - Saag, Michael

AU - Cropsey, Karen

PY - 2016/3/1

Y1 - 2016/3/1

N2 - Opioids are often prescribed for chronic pain, and opioid risks such as overdose and death are heightened when opioids are co-prescribed with other sedating medications. We investigated factors associated with chronic opioid prescription, alone and in combination with benzodiazepines and muscle relaxants, in a clinical cohort of individuals with HIV. We used multivariable logistic regression models to determine participant clinical and demographic characteristics that are associated with chronic prescription of opioids or chronic co-prescription of opioids with sedating medications. Among 1474 participants, chronic prescription of opioids occurred in 253 individuals (17.2 %), and chronic co-prescription occurred in 90 individuals (6.1 %). Age >50, public insurance as compared to private insurance, and symptoms of depression and anxiety were significantly associated with chronic opioid prescription and chronic co-prescription. Our findings raise concern that opioid prescription and co-prescription of sedating medications occurs disproportionately in patients for whom use is riskier.

AB - Opioids are often prescribed for chronic pain, and opioid risks such as overdose and death are heightened when opioids are co-prescribed with other sedating medications. We investigated factors associated with chronic opioid prescription, alone and in combination with benzodiazepines and muscle relaxants, in a clinical cohort of individuals with HIV. We used multivariable logistic regression models to determine participant clinical and demographic characteristics that are associated with chronic prescription of opioids or chronic co-prescription of opioids with sedating medications. Among 1474 participants, chronic prescription of opioids occurred in 253 individuals (17.2 %), and chronic co-prescription occurred in 90 individuals (6.1 %). Age >50, public insurance as compared to private insurance, and symptoms of depression and anxiety were significantly associated with chronic opioid prescription and chronic co-prescription. Our findings raise concern that opioid prescription and co-prescription of sedating medications occurs disproportionately in patients for whom use is riskier.

KW - Benzodiazepine

KW - Chronic pain

KW - HIV

KW - Muscle relaxant

KW - Opioid

UR - http://www.scopus.com/inward/record.url?scp=84959456661&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84959456661&partnerID=8YFLogxK

U2 - 10.1007/s10461-015-1178-8

DO - 10.1007/s10461-015-1178-8

M3 - Article

VL - 20

SP - 687

EP - 698

JO - AIDS and Behavior

JF - AIDS and Behavior

SN - 1090-7165

IS - 3

ER -