TY - JOUR
T1 - Factors associated with complicated buprenorphine inductions
AU - Whitley, Susan D.
AU - Sohler, Nancy L.
AU - Kunins, Hillary V.
AU - Giovanniello, Angela
AU - Li, Xuan
AU - Sacajiu, Galit
AU - Cunningham, Chinazo O.
N1 - Funding Information:
This study was supported by HRSA, HIV/AIDS Bureau, Special Projects of NationalSignificance (Grant 6H97HA00247 ), the Center for AIDS Research at theAlbert Einstein College of Medicine and Montefiore Medical Center (NIH AI-51519 ), National Institute on Drug Abuse ( 5R25DA023021 ), and the Robert WoodJohnson Foundation's Harold Amos Medical Faculty Development Program .
PY - 2010/7
Y1 - 2010/7
N2 - Despite data supporting its efficacy, barriers to implementation of buprenorphine for office-based treatment are present. Complications can occur during buprenorphine inductions, yet few published studies have examined this phase of treatment. To examine factors associated with complications during buprenorphine induction, we conducted a retrospective chart review of the first 107 patients receiving buprenorphine treatment in an urban community health center. The primary outcome, defined as complicated induction (precipitated or protracted withdrawal), was observed in 18 (16.8%) patients. Complicated inductions were associated with poorer treatment retention (than routine inductions) and decreased over time. Factors independently associated with complicated inductions included recent use of prescribed methadone, recent benzodiazepine use, no prior experience with buprenorphine, and a low initial dose of buprenorphine/naloxone. Findings from this study and further investigation of patient characteristics and treatment characteristics associated with complicated inductions can help guide buprenorphine treatment strategies.
AB - Despite data supporting its efficacy, barriers to implementation of buprenorphine for office-based treatment are present. Complications can occur during buprenorphine inductions, yet few published studies have examined this phase of treatment. To examine factors associated with complications during buprenorphine induction, we conducted a retrospective chart review of the first 107 patients receiving buprenorphine treatment in an urban community health center. The primary outcome, defined as complicated induction (precipitated or protracted withdrawal), was observed in 18 (16.8%) patients. Complicated inductions were associated with poorer treatment retention (than routine inductions) and decreased over time. Factors independently associated with complicated inductions included recent use of prescribed methadone, recent benzodiazepine use, no prior experience with buprenorphine, and a low initial dose of buprenorphine/naloxone. Findings from this study and further investigation of patient characteristics and treatment characteristics associated with complicated inductions can help guide buprenorphine treatment strategies.
KW - Buprenorphine
KW - Buprenorphine induction
KW - Opioid dependence
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U2 - 10.1016/j.jsat.2010.04.001
DO - 10.1016/j.jsat.2010.04.001
M3 - Article
C2 - 20682186
AN - SCOPUS:77953585892
SN - 0740-5472
VL - 39
SP - 51
EP - 57
JO - Journal of Substance Abuse Treatment
JF - Journal of Substance Abuse Treatment
IS - 1
ER -
