Factors and temporal trends associated with highly active antiretroviral therapy discontinuation in the Women's Interagency HIV Study

Linda Ahdieh-Grant, Patrick M. Tarwater, Michael F. Schneider, Kathryn Anastos, Mardge Cohen, Ann Khalsa, Howard Minkoff, Mary Young, Ruth M. Greenblatt

Research output: Contribution to journalArticle

31 Scopus citations

Abstract

We characterized factors and temporal trends associated with discontinuation of highly active antiretroviral therapy (HAART) among 936 HIV-infected women enrolled in the Women's Inter-agency HIV Study. A multivariate analysis of post-HAART initiation exposures found that high HIV RNA levels (relative hazard [RH] = 1.36, P < 0.001) and high depressive symptom scores (RH = 1.53, P = 0.012) were associated with HAART discontinuation. The adjusted hazard of discontinuation was higher in the 2 most recent calendar periods compared with the first (RH =1.61, P = 0.026; RH = 1.56, P = 0.074, respectively). The increasing risk of HAART discontinuation in recent calendar periods and changes in the clinical factors associated with discontinuation reflect ongoing and dynamic shifts in the approach to HAART utilization.

Original languageEnglish (US)
Pages (from-to)500-503
Number of pages4
JournalJournal of Acquired Immune Deficiency Syndromes
Volume38
Issue number4
DOIs
StatePublished - Apr 1 2005

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Keywords

  • Antiretroviral therapy
  • Cohort studies
  • Discontinuation
  • HIV/AIDS

ASJC Scopus subject areas

  • Infectious Diseases
  • Pharmacology (medical)

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