Factors associated with poor anticoagulation control with vitamin K antagonists among outpatients attended in Internal Medicine and Neurology. The ALADIN study

en nombre de los investigadores del estudio ALADIN, Listado de investigadores del estudio ALADIN

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10 Scopus citations

Abstract

Objective: To identify factors associated with poor anticoagulation control with vitamin K antagonists (VKA) among outpatients with nonvalvular atrial fibrillation (NVAF) attended in Neurology and Internal Medicine in Spain. Methods: Cross-sectional and multicenter study, from the ALADIN database, of outpatients with NVAF treated with VKA and attended in Internal Medicine and Neurology in Spain. Rates of anticoagulation control were determined with the direct and Rosendaal methods, considering data from the 6 months before the inclusion. Results: Out of 1,337 patients included in the ALADIN study, 750 were taking VKA, and complete information about INR values in the last 6 months was available in 383 patients. Mean scores of Charlson Index, CHADS2, CHA2DS2-VASc and HAS-BLED were 1.94 ± 1.54; 3.10 ± 1.26; 4.63 ± 1.54, and 2.20 ± 0.90, respectively. 46.2% and 47.0% of patients had an adequate anticoagulation control according to the direct and Rosendaal methods, respectively. Inadequate anticoagulation control according to the direct method was associated with diabetes (OR: 2.511; 95% CI: 1.144-5.659), prior labile INR (OR: 35.371; 95% CI: 15.058-83.083) and the determination of > 6 INR controls in the last 6 months (OR: 4.747; 95% CI: 2.094-10.759), and according to the Rosendaal method, with prior labile INR (P <.001) and HAS-BLED score (OR: 3.991; 95% CI: 2.520-6.319). Conclusions: Despite the high thromboembolic risk, only a little more than a half of patients were well controlled. Factors associated with poor anticoagulation control were diabetes, labile INR, > 6 INR controls and HAS-BLED.

Original languageEnglish (US)
Pages (from-to)327-335
Number of pages9
JournalRevista Clinica Espanola
Volume218
Issue number7
DOIs
StatePublished - Oct 2018

Keywords

  • Acenocoumarol
  • Anticoagulation
  • Atrial fibrillation
  • Internal Medicine
  • Neurology
  • Vitamin K antagonists
  • Warfarin

ASJC Scopus subject areas

  • General Medicine

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