Facilitators and barriers to successful recruitment into a large comparative effectiveness trial: a qualitative study

Stephanie Behringer-Massera, Terysia Browne, Geny George, Sally Duran, Andrea Cherrington, Melissa D. McKee, Grade Research Group

Research output: Contribution to journalArticle


Background: Recruitment of participants into research studies, especially individuals from minority groups, is challenging; lack of diversity may lead to biased findings. Aim: To explore beliefs about research participation among individuals who were approached and eligible for the GRADE study. Methods: In-depth qualitative telephone interviews with randomized participants (n = 25) and eligible individuals who declined to enroll (n = 26). Results: Refusers and consenters differed in trust and perceptions of risk, benefits and burden of participation. Few participants understood how comparative effectiveness research differed from other types of trials; however, some features of comparative effectiveness research were perceived as lower risk. Conclusion: We identified facilitators and addressable barriers to participation in research studies.

Original languageEnglish (US)
Pages (from-to)815-826
Number of pages12
JournalJournal of comparative effectiveness research
Issue number10
Publication statusPublished - Jul 1 2019



  • comparative effectiveness research
  • qualitative research
  • recruitment

ASJC Scopus subject areas

  • Health Policy

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