Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol

E. L. Gardner, W. Paredes, D. Smith, A. Donner, C. Milling, D. Cohen, D. Morrison

Research output: Contribution to journalArticle

180 Scopus citations

Abstract

The present experiment explored whether Δ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm. Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalPsychopharmacology
Volume96
Issue number1
DOIs
StatePublished - Sep 1 1988

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Keywords

  • Brain stimulation reward
  • Cannabinoids
  • Cannabis
  • ICSS
  • Intracranial self-stimulation
  • Marijuana
  • Medial forebrain bundle
  • Rat
  • Reinforcement
  • THC
  • Δ-tetrahydrocannabinol

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gardner, E. L., Paredes, W., Smith, D., Donner, A., Milling, C., Cohen, D., & Morrison, D. (1988). Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol. Psychopharmacology, 96(1), 142-144. https://doi.org/10.1007/BF02431546