Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol

E. L. Gardner, William Paredes, D. Smith, A. Donner, C. Milling, D. Cohen, D. Morrison

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

The present experiment explored whether Δ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm. Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.

Original languageEnglish (US)
Pages (from-to)142-144
Number of pages3
JournalPsychopharmacology
Volume96
Issue number1
DOIs
StatePublished - Sep 1988

Fingerprint

Self Stimulation
Dronabinol
Cannabis
Reward
Street Drugs
Brain
Medial Forebrain Bundle
Implanted Electrodes
Aptitude
Pleasure

Keywords

  • Δ-tetrahydrocannabinol
  • Brain stimulation reward
  • Cannabinoids
  • Cannabis
  • ICSS
  • Intracranial self-stimulation
  • Marijuana
  • Medial forebrain bundle
  • Rat
  • Reinforcement
  • THC

ASJC Scopus subject areas

  • Pharmacology

Cite this

Gardner, E. L., Paredes, W., Smith, D., Donner, A., Milling, C., Cohen, D., & Morrison, D. (1988). Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol. Psychopharmacology, 96(1), 142-144. https://doi.org/10.1007/BF02431546

Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol. / Gardner, E. L.; Paredes, William; Smith, D.; Donner, A.; Milling, C.; Cohen, D.; Morrison, D.

In: Psychopharmacology, Vol. 96, No. 1, 09.1988, p. 142-144.

Research output: Contribution to journalArticle

Gardner, EL, Paredes, W, Smith, D, Donner, A, Milling, C, Cohen, D & Morrison, D 1988, 'Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol', Psychopharmacology, vol. 96, no. 1, pp. 142-144. https://doi.org/10.1007/BF02431546
Gardner, E. L. ; Paredes, William ; Smith, D. ; Donner, A. ; Milling, C. ; Cohen, D. ; Morrison, D. / Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol. In: Psychopharmacology. 1988 ; Vol. 96, No. 1. pp. 142-144.
@article{e2161dbd69214ec197e7dfb63da9607c,
title = "Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol",
abstract = "The present experiment explored whether Δ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm. Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.",
keywords = "Δ-tetrahydrocannabinol, Brain stimulation reward, Cannabinoids, Cannabis, ICSS, Intracranial self-stimulation, Marijuana, Medial forebrain bundle, Rat, Reinforcement, THC",
author = "Gardner, {E. L.} and William Paredes and D. Smith and A. Donner and C. Milling and D. Cohen and D. Morrison",
year = "1988",
month = "9",
doi = "10.1007/BF02431546",
language = "English (US)",
volume = "96",
pages = "142--144",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Facilitation of brain stimulation reward by Δ 9-tetrahydrocannabinol

AU - Gardner, E. L.

AU - Paredes, William

AU - Smith, D.

AU - Donner, A.

AU - Milling, C.

AU - Cohen, D.

AU - Morrison, D.

PY - 1988/9

Y1 - 1988/9

N2 - The present experiment explored whether Δ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm. Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.

AB - The present experiment explored whether Δ 9-tetrahydrocannabinol (Δ 9-THC), the psychoactive ingredient in marijuana, shares with other drugs of abuse the ability to facilitate brain stimulation reward acutely, as measured by clectrical intracranial self-stimulation (ICSS). Laboratory rats were implanted with stimulation electrodes in the medial forebrain bundle, and trained to stable performance on a self-titrating threshold ICSS paradigm. Δ 9-THC, at a dose believed pharmacologically relevant to moderate human use of marijuana, acutely lowered ICSS thresholds, suggesting that marijuana acts on similar CNS hedonic systems to most other drugs of abuse.

KW - Δ-tetrahydrocannabinol

KW - Brain stimulation reward

KW - Cannabinoids

KW - Cannabis

KW - ICSS

KW - Intracranial self-stimulation

KW - Marijuana

KW - Medial forebrain bundle

KW - Rat

KW - Reinforcement

KW - THC

UR - http://www.scopus.com/inward/record.url?scp=0023710249&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023710249&partnerID=8YFLogxK

U2 - 10.1007/BF02431546

DO - 10.1007/BF02431546

M3 - Article

VL - 96

SP - 142

EP - 144

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 1

ER -