Extragenital adenosarcoma: A case report, review of the literature, and management discussion

Gloria S. Huang, Rebecca C. Arend, Antoinette Sakaris, Tiffany M. Hebert, Gary L. Goldberg

Research output: Contribution to journalArticle

19 Scopus citations

Abstract

Background: Müllerian adenosarcoma is a rare mixed epithelial-mesenchymal tumor. An extragenital site of origin and sarcomatous overgrowth are associated with aggressive clinical behavior. Case: We present a rare case of extragenital adenosarcoma with sarcomatous overgrowth and coexistent endometriosis. She was treated with initial cytoreductive surgery and chemotherapy. She underwent a second surgery for management of a high-grade bowel obstruction, due to pathologically confirmed recurrent intraperitoneal adenosarcoma. A complete clinical response was achieved with liposomal doxorubicin, and the patient remains disease-free eighteen months after completion of chemotherapy. Conclusion: Liposomal doxorubicin appears to be an active agent for the treatment of adenosarcoma with sarcomatous overgrowth. In addition, we conclude from our review of all reported cases of extragenital adenosarcoma that concurrent endometriosis may represent a favorable prognostic factor.

Original languageEnglish (US)
Pages (from-to)472-475
Number of pages4
JournalGynecologic Oncology
Volume115
Issue number3
DOIs
StatePublished - Dec 1 2009

Keywords

  • Adenosarcoma
  • Chemotherapy
  • Endometriosis
  • Sarcoma

ASJC Scopus subject areas

  • Oncology
  • Obstetrics and Gynecology

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