Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit

H. Sakurai, M. Maeda, K. Miyahara, M. Nakayama, H. Murayama, H. Hasegawa, M. Hayakawa, T. Sugiura, K. Kamikura

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

We measured levels of di-2-ethylhexyl phthalate (DEHP) in a priming solution of a cardiopulmonary bypass circuit. The circuit consisted of a venous reservoir, an oxygenator, and polyvinyl chloride (PVC) tubes. Eight circuits were used in this study. In 4 circuits a heparin-coating PVC tube was used and, in the others, a non-coating PVC tube. After they were primed with 1,500 ml of saline, the saline was circulated for 30 minutes at a rate of 6 l/min at 42 degrees C. Another four samples were collected directly from the saline in a polyethylene container as a control. Then the concentrations of DEHP in them were determined by means of gas chromatography. No detectable DEHP was found in controls. But, a small amount was detected in the saline from the circuits (2.75 +/- 4.27 ppb, and 3.75 +/- 4.99 ppb, respectively). DEHP was considered to be leached from the circuit to the priming solution because the tubes were made of PVC containing DEHP as a plasticizer. We suppose the DEHP concentration is probably at a safe level. However, the data on the endocrinologically toxic level of blood DEHP are insufficient. Therefore, the use of plastic in a circuit may require closer scrutiny to determine whether DEHP leached from PVC contributes to exposure to xenoestrogens.

Original languageEnglish (US)
Pages (from-to)471-474
Number of pages4
JournalKyobu geka. The Japanese journal of thoracic surgery
Volume54
Issue number6
StatePublished - Jun 2001
Externally publishedYes

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Cardiopulmonary Bypass
Polyvinyl Chloride
Oxygenators
Plasticizers
Vascular Access Devices
phthalic acid
Poisons
Polyethylene
Gas Chromatography
Plastics
Heparin

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Sakurai, H., Maeda, M., Miyahara, K., Nakayama, M., Murayama, H., Hasegawa, H., ... Kamikura, K. (2001). Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit. Kyobu geka. The Japanese journal of thoracic surgery, 54(6), 471-474.

Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit. / Sakurai, H.; Maeda, M.; Miyahara, K.; Nakayama, M.; Murayama, H.; Hasegawa, H.; Hayakawa, M.; Sugiura, T.; Kamikura, K.

In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 54, No. 6, 06.2001, p. 471-474.

Research output: Contribution to journalArticle

Sakurai, H, Maeda, M, Miyahara, K, Nakayama, M, Murayama, H, Hasegawa, H, Hayakawa, M, Sugiura, T & Kamikura, K 2001, 'Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit', Kyobu geka. The Japanese journal of thoracic surgery, vol. 54, no. 6, pp. 471-474.
Sakurai H, Maeda M, Miyahara K, Nakayama M, Murayama H, Hasegawa H et al. Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit. Kyobu geka. The Japanese journal of thoracic surgery. 2001 Jun;54(6):471-474.
Sakurai, H. ; Maeda, M. ; Miyahara, K. ; Nakayama, M. ; Murayama, H. ; Hasegawa, H. ; Hayakawa, M. ; Sugiura, T. ; Kamikura, K. / Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit. In: Kyobu geka. The Japanese journal of thoracic surgery. 2001 ; Vol. 54, No. 6. pp. 471-474.
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