Abstract
We measured levels of di-2-ethylhexyl phthalate (DEHP) in a priming solution of a cardiopulmonary bypass circuit. The circuit consisted of a venous reservoir, an oxygenator, and polyvinyl chloride (PVC) tubes. Eight circuits were used in this study. In 4 circuits a heparin-coating PVC tube was used and, in the others, a non-coating PVC tube. After they were primed with 1,500 ml of saline, the saline was circulated for 30 minutes at a rate of 6 l/min at 42 degrees C. Another four samples were collected directly from the saline in a polyethylene container as a control. Then the concentrations of DEHP in them were determined by means of gas chromatography. No detectable DEHP was found in controls. But, a small amount was detected in the saline from the circuits (2.75 +/- 4.27 ppb, and 3.75 +/- 4.99 ppb, respectively). DEHP was considered to be leached from the circuit to the priming solution because the tubes were made of PVC containing DEHP as a plasticizer. We suppose the DEHP concentration is probably at a safe level. However, the data on the endocrinologically toxic level of blood DEHP are insufficient. Therefore, the use of plastic in a circuit may require closer scrutiny to determine whether DEHP leached from PVC contributes to exposure to xenoestrogens.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 471-474 |
| Number of pages | 4 |
| Journal | Kyobu geka. The Japanese journal of thoracic surgery |
| Volume | 54 |
| Issue number | 6 |
| State | Published - Jun 2001 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Medicine(all)
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Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit. / Sakurai, H.; Maeda, M.; Miyahara, K.; Nakayama, M.; Murayama, H.; Hasegawa, H.; Hayakawa, M.; Sugiura, T.; Kamikura, K.
In: Kyobu geka. The Japanese journal of thoracic surgery, Vol. 54, No. 6, 06.2001, p. 471-474.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit
AU - Sakurai, H.
AU - Maeda, M.
AU - Miyahara, K.
AU - Nakayama, M.
AU - Murayama, H.
AU - Hasegawa, H.
AU - Hayakawa, M.
AU - Sugiura, T.
AU - Kamikura, K.
PY - 2001/6
Y1 - 2001/6
N2 - We measured levels of di-2-ethylhexyl phthalate (DEHP) in a priming solution of a cardiopulmonary bypass circuit. The circuit consisted of a venous reservoir, an oxygenator, and polyvinyl chloride (PVC) tubes. Eight circuits were used in this study. In 4 circuits a heparin-coating PVC tube was used and, in the others, a non-coating PVC tube. After they were primed with 1,500 ml of saline, the saline was circulated for 30 minutes at a rate of 6 l/min at 42 degrees C. Another four samples were collected directly from the saline in a polyethylene container as a control. Then the concentrations of DEHP in them were determined by means of gas chromatography. No detectable DEHP was found in controls. But, a small amount was detected in the saline from the circuits (2.75 +/- 4.27 ppb, and 3.75 +/- 4.99 ppb, respectively). DEHP was considered to be leached from the circuit to the priming solution because the tubes were made of PVC containing DEHP as a plasticizer. We suppose the DEHP concentration is probably at a safe level. However, the data on the endocrinologically toxic level of blood DEHP are insufficient. Therefore, the use of plastic in a circuit may require closer scrutiny to determine whether DEHP leached from PVC contributes to exposure to xenoestrogens.
AB - We measured levels of di-2-ethylhexyl phthalate (DEHP) in a priming solution of a cardiopulmonary bypass circuit. The circuit consisted of a venous reservoir, an oxygenator, and polyvinyl chloride (PVC) tubes. Eight circuits were used in this study. In 4 circuits a heparin-coating PVC tube was used and, in the others, a non-coating PVC tube. After they were primed with 1,500 ml of saline, the saline was circulated for 30 minutes at a rate of 6 l/min at 42 degrees C. Another four samples were collected directly from the saline in a polyethylene container as a control. Then the concentrations of DEHP in them were determined by means of gas chromatography. No detectable DEHP was found in controls. But, a small amount was detected in the saline from the circuits (2.75 +/- 4.27 ppb, and 3.75 +/- 4.99 ppb, respectively). DEHP was considered to be leached from the circuit to the priming solution because the tubes were made of PVC containing DEHP as a plasticizer. We suppose the DEHP concentration is probably at a safe level. However, the data on the endocrinologically toxic level of blood DEHP are insufficient. Therefore, the use of plastic in a circuit may require closer scrutiny to determine whether DEHP leached from PVC contributes to exposure to xenoestrogens.
UR - http://www.scopus.com/inward/record.url?scp=0035379991&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0035379991&partnerID=8YFLogxK
M3 - Article
C2 - 11424496
AN - SCOPUS:0035379991
VL - 54
SP - 471
EP - 474
JO - Kyobu geka. The Japanese journal of thoracic surgery
JF - Kyobu geka. The Japanese journal of thoracic surgery
SN - 0021-5252
IS - 6
ER -