TY - JOUR
T1 - Extracorporeal membrane oxygenation for adult respiratory failure
AU - Peek, G. J.
AU - Moore, H. M.
AU - Moore, N.
AU - Sosnowski, A. W.
AU - Firmin, R. K.
N1 - Funding Information:
Heartlink ECMO Centre receives support from Heartlink Children's Charity. Dr. Peek is the holder of a British Heart Foundation, Junior Research Fellowship.
PY - 1997
Y1 - 1997
N2 - Objectives: To review the first 50 patients to receive extracorporeal membrane oxygenation (ECMO) for respiratory failure at Glenfield Hospital, and to compare them with published series of patients receiving positive pressure ventilation. Design: Retrospective chart review. Setting: Extracorporeal Life Support Organization/European Extracorporeal Life Support Organization recognized ECMO center. Patients: Fifty consecutive patients referred for ECMO with respiratory failure refractory to conventional management between 1989 and 1995. Interventions: None. Measurements and results: Primary end point was survival to hospital discharge, 66%. Other data (mean and SD): Murray Lung Injury Score, 3.4 (0.5); ratio of PaO2 to fraction of inspired oxygen, 65 (36.9) mm Hg; duration of ventilation pre- ECMO, 76.5 (83.7 h); peak airway pressure, 30.6 (7.4) cm H2O; end- expiratory pressure, 10 (3.3) em H2O; minute ventilation, 12.6 (3.32) L/min; age, 30.1 (10.8) years; duration of ECMO, 207.4 (177.8) h; and units of blood transfused, 19 (17.3). Survival was significantly better than two previously reported series of patients receiving positive pressure ventilation (55.6% and 42% survival), p=0.036 and p=0.0006. Odds ratio for improved survival was 0.46 (95% confidence interval, 0.22 to 0.97, p=0.036). Conclusions: Survival with ECMO is 66% for adults with severe respiratory failure. ECMO should be considered in patients who remain hypoxic despite maximal positive pressure ventilation.
AB - Objectives: To review the first 50 patients to receive extracorporeal membrane oxygenation (ECMO) for respiratory failure at Glenfield Hospital, and to compare them with published series of patients receiving positive pressure ventilation. Design: Retrospective chart review. Setting: Extracorporeal Life Support Organization/European Extracorporeal Life Support Organization recognized ECMO center. Patients: Fifty consecutive patients referred for ECMO with respiratory failure refractory to conventional management between 1989 and 1995. Interventions: None. Measurements and results: Primary end point was survival to hospital discharge, 66%. Other data (mean and SD): Murray Lung Injury Score, 3.4 (0.5); ratio of PaO2 to fraction of inspired oxygen, 65 (36.9) mm Hg; duration of ventilation pre- ECMO, 76.5 (83.7 h); peak airway pressure, 30.6 (7.4) cm H2O; end- expiratory pressure, 10 (3.3) em H2O; minute ventilation, 12.6 (3.32) L/min; age, 30.1 (10.8) years; duration of ECMO, 207.4 (177.8) h; and units of blood transfused, 19 (17.3). Survival was significantly better than two previously reported series of patients receiving positive pressure ventilation (55.6% and 42% survival), p=0.036 and p=0.0006. Odds ratio for improved survival was 0.46 (95% confidence interval, 0.22 to 0.97, p=0.036). Conclusions: Survival with ECMO is 66% for adults with severe respiratory failure. ECMO should be considered in patients who remain hypoxic despite maximal positive pressure ventilation.
KW - ARDS
KW - ECMO
KW - Survival
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U2 - 10.1378/chest.112.3.759
DO - 10.1378/chest.112.3.759
M3 - Article
C2 - 9315812
AN - SCOPUS:0030843378
SN - 0012-3692
VL - 112
SP - 759
EP - 764
JO - Diseases of the chest
JF - Diseases of the chest
IS - 3
ER -