Extracorporeal and advanced therapies for progressive refractory near-fatal acute severe asthma in children

Shivanand S. Medar, Giles J. Peek, Deepa Rastogi

Research output: Contribution to journalReview article

Abstract

Asthma is the most common chronic illness and is one of the most common medical emergencies in children. Progressive refractory near-fatal asthma requiring intubation and mechanical ventilation can lead to death. Extracorporeal membrane oxygenation (ECMO) can provide adequate gas exchange during acute respiratory failure although data on outcomes in children requiring ECMO support for status asthmaticus is sparse with one study reporting survival rates of nearly 85% with asthma being one of the best outcome subsets for patients with refractory respiratory failure requiring ECMO support. We describe the current literature on the use of ECMO and other advanced extracorporeal therapies available for children with acute severe asthma. We also review other advanced invasive and noninvasive therapies in acute severe asthma both before and while on ECMO support.

Original languageEnglish (US)
Pages (from-to)1311-1319
Number of pages9
JournalPediatric pulmonology
Volume55
Issue number6
DOIs
StatePublished - Jun 1 2020

Keywords

  • asthma
  • ECMO
  • near-fatal asthma
  • refractory asthma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

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