Abstract
Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.
Original language | English (US) |
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Pages (from-to) | 58-63 |
Number of pages | 6 |
Journal | Mechanisms of Ageing and Development |
Volume | 128 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2007 |
Externally published | Yes |
Keywords
- Adaptive stress response
- Ageing
- Base excision repair
- DNA damage
- Nucleotide excision repair
- Progeria
- SIRT6
ASJC Scopus subject areas
- Aging
- Developmental Biology