Extended longevity mechanisms in short-lived progeroid mice: Identification of a preservative stress response associated with successful aging

Marieke van de Ven, Jaan Olle Andressoo, Valerie B. Holcomb, Paul Hasty, Yousin Suh, Harry van Steeg, George A. Garinis, Jan H.J. Hoeijmakers, James R. Mitchell

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Semantic distinctions between "normal" aging, "pathological" aging (or age-related disease) and "premature" aging (otherwise known as segmental progeria) potentially confound important insights into the nature of each of the complex processes. Here we review a recent, unexpected discovery: the presence of longevity-associated characteristics typical of long-lived endocrine-mutant and dietary-restricted animals in short-lived progeroid mice. These data suggest that a subset of symptoms observed in premature aging, and possibly normal aging as well, may be indirect manifestations of a beneficial adaptive stress response to endogenous oxidative damage, rather than a detrimental result of the damage itself.

Original languageEnglish (US)
Pages (from-to)58-63
Number of pages6
JournalMechanisms of Ageing and Development
Volume128
Issue number1
DOIs
StatePublished - Jan 2007

Keywords

  • Adaptive stress response
  • Ageing
  • Base excision repair
  • DNA damage
  • Nucleotide excision repair
  • Progeria
  • SIRT6

ASJC Scopus subject areas

  • Aging
  • Developmental Biology

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