Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis

Donald Douglas Raum, Z. Awdeh, D. Glass, G. Kammer, M. A. Khan, J. S. Coblyn, M. Weinblatt, D. Holdsworth, L. Strong, R. D. Rossen

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA-B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA-B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease-associated chromosomes.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalArthritis and Rheumatism
Volume27
Issue number5
StatePublished - 1984
Externally publishedYes

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Chromosomes, Human, Pair 6
Haplotypes
Rheumatoid Arthritis
HLA-B15 Antigen
HLA-DR4 Antigen
HLA-B Antigens
Linkage Disequilibrium
HLA-DR Antigens
Chromosomes
Alleles

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Raum, D. D., Awdeh, Z., Glass, D., Kammer, G., Khan, M. A., Coblyn, J. S., ... Rossen, R. D. (1984). Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis. Arthritis and Rheumatism, 27(5), 516-521.

Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis. / Raum, Donald Douglas; Awdeh, Z.; Glass, D.; Kammer, G.; Khan, M. A.; Coblyn, J. S.; Weinblatt, M.; Holdsworth, D.; Strong, L.; Rossen, R. D.

In: Arthritis and Rheumatism, Vol. 27, No. 5, 1984, p. 516-521.

Research output: Contribution to journalArticle

Raum, DD, Awdeh, Z, Glass, D, Kammer, G, Khan, MA, Coblyn, JS, Weinblatt, M, Holdsworth, D, Strong, L & Rossen, RD 1984, 'Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis', Arthritis and Rheumatism, vol. 27, no. 5, pp. 516-521.
Raum DD, Awdeh Z, Glass D, Kammer G, Khan MA, Coblyn JS et al. Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis. Arthritis and Rheumatism. 1984;27(5):516-521.
Raum, Donald Douglas ; Awdeh, Z. ; Glass, D. ; Kammer, G. ; Khan, M. A. ; Coblyn, J. S. ; Weinblatt, M. ; Holdsworth, D. ; Strong, L. ; Rossen, R. D. / Extended haplotypes of chromosome 6 in the adult rheumatoid arthritis. In: Arthritis and Rheumatism. 1984 ; Vol. 27, No. 5. pp. 516-521.
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AU - Awdeh, Z.

AU - Glass, D.

AU - Kammer, G.

AU - Khan, M. A.

AU - Coblyn, J. S.

AU - Weinblatt, M.

AU - Holdsworth, D.

AU - Strong, L.

AU - Rossen, R. D.

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