TY - JOUR
T1 - Extended haplotypes of chromosome 6 in adult rheumatoid arthritis
AU - Raum, D.
AU - Awdeh, Z.
AU - Glass, D.
AU - Kammer, G.
AU - Khan, M. A.
AU - Coblyn, J. S.
AU - Weinblatt, M.
AU - Holdsworth, D.
AU - Strong, L.
AU - Rossen, R. D.
AU - Brewer, E.
AU - Yunis, E.
AU - Alper, C. A.
PY - 1984/5
Y1 - 1984/5
N2 - In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.
AB - In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.
UR - http://www.scopus.com/inward/record.url?scp=0021341139&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021341139&partnerID=8YFLogxK
U2 - 10.1002/art.1780270506
DO - 10.1002/art.1780270506
M3 - Article
C2 - 6586181
AN - SCOPUS:0021341139
SN - 0004-3591
VL - 27
SP - 516
EP - 521
JO - Arthritis & Rheumatism
JF - Arthritis & Rheumatism
IS - 5
ER -