Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

D. Raum, Z. Awdeh, D. Glass, G. Kammer, M. A. Khan, J. S. Coblyn, M. Weinblatt, D. Holdsworth, L. Strong, R. D. Rossen, E. Brewer, E. Yunis, C. A. Alper

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalArthritis & Rheumatism
Volume27
Issue number5
DOIs
StatePublished - May 1984
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

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    Raum, D., Awdeh, Z., Glass, D., Kammer, G., Khan, M. A., Coblyn, J. S., Weinblatt, M., Holdsworth, D., Strong, L., Rossen, R. D., Brewer, E., Yunis, E., & Alper, C. A. (1984). Extended haplotypes of chromosome 6 in adult rheumatoid arthritis. Arthritis & Rheumatism, 27(5), 516-521. https://doi.org/10.1002/art.1780270506