Extended haplotypes of chromosome 6 in adult rheumatoid arthritis

D. Raum, Z. Awdeh, D. Glass, G. Kammer, M. A. Khan, J. S. Coblyn, M. Weinblatt, D. Holdsworth, L. Strong, R. D. Rossen, E. Brewer, E. Yunis, C. A. Alper

Research output: Contribution to journalArticle

18 Scopus citations


In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P < 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA‐B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA—‐B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P < 0.001) among whites with the disease‐associated chromosomes.

Original languageEnglish (US)
Pages (from-to)516-521
Number of pages6
JournalArthritis & Rheumatism
Issue number5
StatePublished - May 1984
Externally publishedYes


ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Raum, D., Awdeh, Z., Glass, D., Kammer, G., Khan, M. A., Coblyn, J. S., Weinblatt, M., Holdsworth, D., Strong, L., Rossen, R. D., Brewer, E., Yunis, E., & Alper, C. A. (1984). Extended haplotypes of chromosome 6 in adult rheumatoid arthritis. Arthritis & Rheumatism, 27(5), 516-521. https://doi.org/10.1002/art.1780270506