Expression pattern of two Frizzled-related genes, Frzb-1 and Sfrp-1, during mouse embryogenesis suggests a role for modulating action of Wnt family members

Bang H. Hoang, J. Terrig Thomas, Fadi W. Abdul-Karim, Kristen M. Correia, Ronald A. Conlon, Frank P. Luyten, R. Tracy Ballock

Research output: Contribution to journalArticle

74 Scopus citations


Wnt proteins have been implicated in regulating growth and pattern formation in a variety of tissues during embryonic development. We previously identified Frzb-1, a gene which encodes a secreted protein with homology in the ligand binding domain to the Wnt receptor Frizzled, but lacking the domain encoding the putative seven transmembrane segments. Frzb-1 has recently been shown to bind to Wnt proteins in vitro, and to inhibit the activity of Xenopus Wnt-8 in vivo. We report now that mFrzb-1 and Wnt transcripts display both complementary and overlapping expression patterns at multiple sites throughout embryonic development. By Northern analysis, the expression of mFrzb-1 in the developing mouse embryo is greatest from 10.5 to 12.5 days postcoitum (dpc). In the early embryo, mFrzb-1 is expressed in the primitive streak, presomitic mesoderm, somites, and brain. Later, mFrzb-1 exhibits sharp boundaries of expression in the limb bud, branchial arches, facial mesenchyme, and in cartilaginous elements of the appendicular skeleton. We conclude from these experiments that Frzb-1 is expressed at a time and location to modulate the action of Wnt family members during development of the limbs and central nervous system.

Original languageEnglish (US)
Pages (from-to)364-372
Number of pages9
JournalDevelopmental Dynamics
Issue number3
Publication statusPublished - Jul 1 1998
Externally publishedYes



  • Embryogenesis
  • Frizzled-like proteins
  • Limb
  • Mouse
  • Wnt

ASJC Scopus subject areas

  • Developmental Biology

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