Expression of the rheumatoid factor Cross-reactive ldiotype in JRA: Association with disease onset subtype, disease activi and disease severity

N. T. Ilowite, M. E. O'reilly, L. Hatam, J. F. Wedgwood, V. R. Bonagura

Research output: Contribution to journalArticle

4 Scopus citations


Ilowite NT, O'Reilly ME, Hatam L, Wedgwood JF, Bonagura VR. Expression of the Rheumatoid Factor Cross-reactive Idiotype in JRA: Association with Disease Onset Subtype, Disease Activity and Disease Severity. Scand J Rheumatol. 1992; 21: 51-4. We previously reported that approximately one-third of patients with juvenile rheumatoid arthritis (JRA) express high concentrations of antibodies marked by the rheumatoid factor cross reactive idiotype (RCRI) in their sera (6). In order to determine if an expression of RCRI is associated with certain clinical features of the disease, we prospectively studied 49 patients with JRA over a six month period, and determined serum RCRI concentrations by inhibition ELISA. RCRI concentrations correlated significantly with the duration of morning stiffness (r =. 3866, p <01), and the functional class (p<001), but not with the number of active joints. Expression of RCRI was higher in patients with systemic onset disease (p<03), compared to patients with pauciarticular or polyarticular disease. In patients studied on more than one occasion, the RCRI expression was relatively constant despite changes in disease activity. A subset of JRA patients with systemic onset disease, significant morning stiffness, and severe arthritis, had higher serum concentrations of the RCRI.

Original languageEnglish (US)
Pages (from-to)51-54
Number of pages4
JournalScandinavian Journal of Rheumatology
Issue number2
StatePublished - Jan 1 1992



  • Cross-reactive idiotype
  • Juvenile rheumatoid arthritis
  • Rheumatoid factor

ASJC Scopus subject areas

  • Immunology and Allergy
  • Rheumatology
  • Immunology

Cite this