TY - JOUR
T1 - Expression of the major rheumatoid factor cross‐reactive idiotype in juvenile rheumatoid arthritis
AU - Ilowite, Norman T.
AU - Wedgwood, Josiah F.
AU - Bonagura, Vincent R.
PY - 1989/3
Y1 - 1989/3
N2 - The major rheumatoid factor cross‐reactive idiotype (RF‐CRI), defined by prototypic monoclonal IgM rheumatoid factors, is expressed in high frequency by pokeweed mitogen–derived plasma cells from patients with rheumatoid arthritis who express RF in their sera. Unlike adults with rheumatoid arthritis, most patients with juvenile rheumatoid arthritis are seronegative for RF, as detected by classic IgG binding assays. We report that ∼50% of seronegative patients with juvenile rheumatoid arthritis express the RF‐CRI in high frequency among their pokeweed mitogen–derived plasma cells, and that ∼33% of patients express the RF‐CRI in high titer in their sera. The possible mechanisms for expression of an idiotypic marker of RF without expression of IgG binding activity by classic assays are discussed.
AB - The major rheumatoid factor cross‐reactive idiotype (RF‐CRI), defined by prototypic monoclonal IgM rheumatoid factors, is expressed in high frequency by pokeweed mitogen–derived plasma cells from patients with rheumatoid arthritis who express RF in their sera. Unlike adults with rheumatoid arthritis, most patients with juvenile rheumatoid arthritis are seronegative for RF, as detected by classic IgG binding assays. We report that ∼50% of seronegative patients with juvenile rheumatoid arthritis express the RF‐CRI in high frequency among their pokeweed mitogen–derived plasma cells, and that ∼33% of patients express the RF‐CRI in high titer in their sera. The possible mechanisms for expression of an idiotypic marker of RF without expression of IgG binding activity by classic assays are discussed.
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U2 - 10.1002/anr.1780320306
DO - 10.1002/anr.1780320306
M3 - Article
C2 - 2930601
AN - SCOPUS:0024544480
VL - 32
SP - 265
EP - 270
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
SN - 2326-5191
IS - 3
ER -