Expression of the major rheumatoid factor cross-reactive idiotype in juvenile rheumatoid arthritis

Norman Todd Ilowite, J. F. Wedgwood, V. R. Bonagura

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12 Citations (Scopus)

Abstract

The major rheumatoid factor cross-reactive idiotype (RF-CRI), defined by prototypic monoclonal IgM rheumatoid factors, is expressed in high frequency by pokeweed mitogen-derived plasma cells from patients with rheumatoid arthritis who express RF in their sera. Unlike adults with rheumatoid arthritis, most patients with juvenile rheumatoid arthritis are seronegative for RF, as detected by classic IgG binding assays. We report that ~ 50% of seronegative patients with juvenile rheumatoid arthritis express the RF-CRI in high frequency among their pokeweed mitogen-derived plasma cells, and that ~ 33% of patients express the RF-CRI in high titer in their sera. The possible mechanisms for expression of an idiotypic marker of RF without expression of IgG binding activity by classic assays are discussed.

Original languageEnglish (US)
Pages (from-to)265-270
Number of pages6
JournalArthritis and Rheumatism
Volume32
Issue number3
StatePublished - 1989

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Juvenile Arthritis
Rheumatoid Factor
Pokeweed Mitogens
Plasma Cells
Rheumatoid Arthritis
Immunoglobulin G
Serum
Immunoglobulin M

ASJC Scopus subject areas

  • Immunology
  • Rheumatology

Cite this

Expression of the major rheumatoid factor cross-reactive idiotype in juvenile rheumatoid arthritis. / Ilowite, Norman Todd; Wedgwood, J. F.; Bonagura, V. R.

In: Arthritis and Rheumatism, Vol. 32, No. 3, 1989, p. 265-270.

Research output: Contribution to journalArticle

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