Expression of stress-response (heat-shock) protein 27 in human brain tumors: an immunohistochemical study

M. Kato, F. Herz, S. Kato, A. Hirano

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Abstract

This report concerns the expression of the low molecular weight stress-response (heat-shock) protein 27 (srp 27) in a variety of human brain tumors. Immunohistochemical techniques were used; cells of the breast cancer line MCF7 served as positive controls. The reaction product was found exclusively in the cytoplasm. Srp 27 was detected in 5/5 breast tumor metastases to the brain and in 5/21 meningiomas. The protein was also detected in 5/11 glioblastomas and 2/5 pituitary adenomas. By comparison, positive staining was observed in only 1/15 astrocytomas and 1/7 medulloblastoma and no reaction was seen with the oligodendrogliomas, schwannomas and gangliogliomas tested. These observations demonstrate that srp 27 is expressed by certain primary intracranial tumors.

Original languageEnglish (US)
Pages (from-to)420-422
Number of pages3
JournalActa neuropathologica
Volume83
Issue number4
DOIs
Publication statusPublished - Jul 1 1992

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Keywords

  • Brain tumors
  • Breast tumor metastases
  • Heat-shock protein
  • Stress-response protein

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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