Expression of protease and protease-inhibitory activity in human mononuclear leukocyte cultures. Effect of conA stimulation

Victor B. Hatcher, Allen J. Norin

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6 Scopus citations


Trypsin-activated protease activity was observed in the supernatants of conA-treated unfractionated or monocyte-depleted cultures at 1 h of incubation and trypsin-inhibitory activity was detected at 24 h. In contrast, supernatants from wheat germ agglutinin (WGA)-treated cultures or untreated cultures exhibited trypsin-inhibitory activity at 1 h and trypsinactivated protease activity after 24 h. The expression of proteases and protease inhibitors may be early events that occur during the activation of quiescent lymphocytes to a proliferative state.

Original languageEnglish (US)
Pages (from-to)471-476
Number of pages6
JournalExperimental Cell Research
Issue number2
Publication statusPublished - Dec 1982


ASJC Scopus subject areas

  • Cell Biology

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