Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer

S. I. Mohammed, K. N.M. Khan, R. S. Sellers, M. G. Hayek, D. B. DeNicola, L. Wu, P. L. Bonney, D. W. Knapp

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86 Scopus citations

Abstract

The purpose of this work was to determine cox-1 and cox-2 expression by immunohistochemistry in forms of naturally occurring canine cancer in order to identify animal systems for pre-clinical evaluation of cox inhibitors and cox-2 inhibitors in cancer. Canine lymphoma (LSA), prostatic carcinoma (PCA), osteosarcoma (OSA), oral melanoma (MEL), oral squamous cell carcinoma (SCC), oral fibrosarcoma (FSA), mammary carcinoma (MCA), and normal tissues were included. Cox-2 was expressed in epithelial tumors (17 of 26 SCC, 8 of 13 MCA, 5 of 9 PCA cases) and MEL (9 of 15 cases), but was generally absent in normal tissues. Cox-2 expression was minimal or absent in mesenchymal tumors and LSA. Cox-1 was expressed in normal epithelial tissues and in some osteoclast and osteoblast in bone, but was absent in normal lymph node. In conclusion, forms of canine cancer were identified for in vivo studies of the effects of cox inhibitors and selective cox-2 inhibitors on cancer.

Original languageEnglish (US)
Pages (from-to)479-483
Number of pages5
JournalProstaglandins Leukotrienes and Essential Fatty Acids
Volume70
Issue number5
DOIs
Publication statusPublished - May 2004

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Keywords

  • Canine
  • Cyclooxygenase
  • Tumors

ASJC Scopus subject areas

  • Clinical Biochemistry
  • Cell Biology

Cite this

Mohammed, S. I., Khan, K. N. M., Sellers, R. S., Hayek, M. G., DeNicola, D. B., Wu, L., ... Knapp, D. W. (2004). Expression of cyclooxygenase-1 and 2 in naturally-occurring canine cancer. Prostaglandins Leukotrienes and Essential Fatty Acids, 70(5), 479-483. https://doi.org/10.1016/j.plefa.2003.10.002