Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation

Andrew Fong, Ediberto Garcia, Lucas Gwynn, Michael P. Lisanti, Melissa J. Fazzari, Maomi Li

Research output: Contribution to journalArticle

91 Citations (Scopus)

Abstract

We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.

Original languageEnglish (US)
Pages (from-to)93-100
Number of pages8
JournalAmerican journal of clinical pathology
Volume120
Issue number1
DOIs
StatePublished - Jul 1 2003

Fingerprint

Caveolin 2
Caveolin 1
Urinary Bladder
Carcinoma
Neoplasms
Urothelium
Carcinoma in Situ
Multivariate Analysis

Keywords

  • Carcinogenesis
  • Caveolin
  • Urinary bladder
  • Urothelial carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation. / Fong, Andrew; Garcia, Ediberto; Gwynn, Lucas; Lisanti, Michael P.; Fazzari, Melissa J.; Li, Maomi.

In: American journal of clinical pathology, Vol. 120, No. 1, 01.07.2003, p. 93-100.

Research output: Contribution to journalArticle

@article{8b48af015b4f4047a90d78ff71e6bd8d,
title = "Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation",
abstract = "We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37{\%}) of 94 cases and 45 (51{\%}) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0{\%} (0/6), 0{\%} (0/25), and 56{\%} (35/63), respectively (P < .001), and for Cav-2, 0{\%} (0/6), 13{\%} (3/23), and 70{\%} (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43{\%} (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.",
keywords = "Carcinogenesis, Caveolin, Urinary bladder, Urothelial carcinoma",
author = "Andrew Fong and Ediberto Garcia and Lucas Gwynn and Lisanti, {Michael P.} and Fazzari, {Melissa J.} and Maomi Li",
year = "2003",
month = "7",
day = "1",
doi = "10.1309/292NHAYNWAVREJ37",
language = "English (US)",
volume = "120",
pages = "93--100",
journal = "American Journal of Clinical Pathology",
issn = "0002-9173",
publisher = "American Society of Clinical Pathologists",
number = "1",

}

TY - JOUR

T1 - Expression of caveolin-1 and caveolin-2 in urothelial carcinoma of the urinary bladder correlates with tumor grade and squamous differentiation

AU - Fong, Andrew

AU - Garcia, Ediberto

AU - Gwynn, Lucas

AU - Lisanti, Michael P.

AU - Fazzari, Melissa J.

AU - Li, Maomi

PY - 2003/7/1

Y1 - 2003/7/1

N2 - We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.

AB - We immunohistochemically evaluated 94 cases of urothelial carcinoma (UC) of the urinary bladder for the expression of caveolin (Cav)-1 and Cav-2. Neither benign urothelium present in 22 cases nor flat carcinoma in situ present in 10 cases stained for Cav-1 or Cav-2. Thirty-five (37%) of 94 cases and 45 (51%) of 89 cases of UC stained positively for Cav-1 and Cav-2, respectively. The percentages of positive cases for Cav-1 in grades 1, 2, and 3 tumors were 0% (0/6), 0% (0/25), and 56% (35/63), respectively (P < .001), and for Cav-2, 0% (0/6), 13% (3/23), and 70% (42/60), respectively (P < .001). Multivariate analysis showed no significant correlation between tumor stage and Cav-1 or Cav-2 expression after correction for tumor grade. Eighty-two percent (14/17) of cases with squamous differentiation were positive for Cav-1 compared with 43% (20/46) of grade 3 tumors without squamous differentiation (P < .001). These results indicate a positive correlation of the expression of Cav-1 and Cav-2 with tumor grade and squamous features of UC and suggest that Cav-1 and Cav-2 be studied further for a possible role in tumor progression and squamous differentiation.

KW - Carcinogenesis

KW - Caveolin

KW - Urinary bladder

KW - Urothelial carcinoma

UR - http://www.scopus.com/inward/record.url?scp=85047687155&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047687155&partnerID=8YFLogxK

U2 - 10.1309/292NHAYNWAVREJ37

DO - 10.1309/292NHAYNWAVREJ37

M3 - Article

C2 - 12866378

AN - SCOPUS:85047687155

VL - 120

SP - 93

EP - 100

JO - American Journal of Clinical Pathology

JF - American Journal of Clinical Pathology

SN - 0002-9173

IS - 1

ER -