Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

E. William St Clair, Charles C. Query, Rex Bentley, Jack D. Keene, Richard P. Polisson, Nancy B. Allen, David S. Caldwell, John R. Rice, Christine Cox, David S. Pisetsky

Research output: Contribution to journalArticle

18 Scopus citations

Abstract

To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.

Original languageEnglish (US)
Pages (from-to)266-280
Number of pages15
JournalClinical Immunology and Immunopathology
Volume54
Issue number2
DOIs
StatePublished - Feb 1990
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

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    Clair, E. W. S., Query, C. C., Bentley, R., Keene, J. D., Polisson, R. P., Allen, N. B., Caldwell, D. S., Rice, J. R., Cox, C., & Pisetsky, D. S. (1990). Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus. Clinical Immunology and Immunopathology, 54(2), 266-280. https://doi.org/10.1016/0090-1229(90)90088-8