Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

E. William St Clair; Charles C. Query; Rex Bentley; Jack D. Keene; Richard P. Polisson; Nancy B. Allen; David S. Caldwell; John R. Rice; Christine Cox; David S. Pisetsky

doi:10.1016/0090-1229(90)90088-8

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

E. William St Clair, Charles C. Query, Rex Bentley, Jack D. Keene, Richard P. Polisson, Nancy B. Allen, David S. Caldwell, John R. Rice, Christine Cox, David S. Pisetsky

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.

Original language	English (US)
Pages (from-to)	266-280
Number of pages	15
Journal	Clinical Immunology and Immunopathology
Volume	54
Issue number	2
DOIs	https://doi.org/10.1016/0090-1229(90)90088-8
State	Published - Feb 1990
Externally published	Yes

ASJC Scopus subject areas

Immunology and Allergy
Pathology and Forensic Medicine
Immunology

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10.1016/0090-1229(90)90088-8

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@article{e077b2b756c141d1b3289a66b925fd75,

title = "Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus",

abstract = "To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.",

author = "Clair, {E. William St} and Query, {Charles C.} and Rex Bentley and Keene, {Jack D.} and Polisson, {Richard P.} and Allen, {Nancy B.} and Caldwell, {David S.} and Rice, {John R.} and Christine Cox and Pisetsky, {David S.}",

note = "Funding Information: {\textquoteright} This work has been supported in part by General Clinical Research Center Grant RROOO30-26S2 from the Division of Research Resources, National Institutes of Health, Maryland, National Institutes of Health Grant AI-23308, and the Arthritis Foundation{\textquoteright}s Devil{\textquoteright}s Bag Award.",

year = "1990",

month = feb,

doi = "10.1016/0090-1229(90)90088-8",

language = "English (US)",

volume = "54",

pages = "266--280",

journal = "Clinical Immunology and Immunopathology",

issn = "0090-1229",

publisher = "Academic Press Inc.",

number = "2",

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TY - JOUR

T1 - Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

AU - Clair, E. William St

AU - Query, Charles C.

AU - Bentley, Rex

AU - Keene, Jack D.

AU - Polisson, Richard P.

AU - Allen, Nancy B.

AU - Caldwell, David S.

AU - Rice, John R.

AU - Cox, Christine

AU - Pisetsky, David S.

N1 - Funding Information: ’ This work has been supported in part by General Clinical Research Center Grant RROOO30-26S2 from the Division of Research Resources, National Institutes of Health, Maryland, National Institutes of Health Grant AI-23308, and the Arthritis Foundation’s Devil’s Bag Award.

PY - 1990/2

Y1 - 1990/2

N2 - To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.

AB - To determine the specificity of antibodies to the (U1) ribonucleoprotein antigen in systemic lupus erythematosus (SLE), patient sera were tested for binding to a recombinant human 70K antigen. By solid-phase immunoassay, we detected anti-70K reactivity in sera from 31 of 96 patients with systemic lupus erythematosus (SLE), demonstrating that anti-70K antibodies may occur in patients with SLE as well as other clinical diagnoses. In sequential sera from 2 of these patients, we found that anti-70K binding varied dramatically over the course of disease. The changes in anti-70K antibody levels did not correlate with clinical events nor evolving antibody reactivity with the Sm-specific antigens.

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JF - Clinical Immunology and Immunopathology

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ER -

Expression of autoantibodies to recombinant (U1) RNP-associated 70K antigen in systemic lupus erythematosus

Abstract

ASJC Scopus subject areas

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