Expression and sequence analyses of p33ING1 gene in myeloid leukemia

K. Ito, K. Kinjo, T. Nakazato, Y. Ikeda, M. Kizaki

Research output: Contribution to journalArticle

17 Scopus citations

Abstract

p33ING1 is a novel candidate tumor suppressor gene which is involved in the regulation of apoptosis. p33ING1 interacts with p53 signaling pathway and regulates cellular growth. It has reported that the expression of p33ING1 mRNA was decreased in lymphoid malignancies. We thus investigated the potential involvement of p33ING1 abnormalities in myeloid leukemias. However, the levels of p33ING1 transcript were almost equal in 3 AML cell lines and 10 fresh AML samples. In addition, neither point mutations nor deletions in p33ING1 gene were found in myeloid leukemias. These results suggest that p33ING1 may not be a major candidate tumor suppressor gene in myeloid leukemias.

Original languageEnglish (US)
Pages (from-to)141-143
Number of pages3
JournalAmerican Journal of Hematology
Volume69
Issue number2
DOIs
StatePublished - Feb 11 2002
Externally publishedYes

Keywords

  • Direct sequence
  • Myeloid leukemia
  • RT-PCR
  • p33
  • p53

ASJC Scopus subject areas

  • Hematology

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