Expression and sequence analyses of p33^ING1 gene in myeloid leukemia

p33^ING1 is a novel candidate tumor suppressor gene which is involved in the regulation of apoptosis. p33^ING1 interacts with p53 signaling pathway and regulates cellular growth. It has reported that the expression of p33^ING1 mRNA was decreased in lymphoid malignancies. We thus investigated the potential involvement of p33^ING1 abnormalities in myeloid leukemias. However, the levels of p33^ING1 transcript were almost equal in 3 AML cell lines and 10 fresh AML samples. In addition, neither point mutations nor deletions in p33^ING1 gene were found in myeloid leukemias. These results suggest that p33^ING1 may not be a major candidate tumor suppressor gene in myeloid leukemias.