Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development

Joseph Yanai, Sharon Dotan, Roman Goz, Adi Pinkas, Frederic J. Seidler, Theodore A. Slotkin, Frederic Zimmerman

Research output: Contribution to journalArticle

25 Scopus citations

Abstract

There is increasing concern over the widespread use of perfluorinated chemicals, which accumulate in various tissues and penetrate the mammalian fetus. A chick model was established for the rapid evaluation of teratogenicity of these chemicals, an important issue because developmental defects often occur at lower exposures than those required for adult systemic toxicity. Chicken eggs were injected with varying doses of perfluorooctanoic acid prior to incubation. Observed were defects in hatching, increased incidence of splayed legs, and interference with the appropriate development of yellow plumage. All these defects are potentially related to essential molecular/biochemical and functional development of the chick. Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses.

Original languageEnglish (US)
Pages (from-to)131-133
Number of pages3
JournalJournal of Toxicology and Environmental Health - Part A: Current Issues
Volume71
Issue number2
DOIs
StatePublished - Jan 1 2008
Externally publishedYes

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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