TY - JOUR
T1 - Exposure of developing chicks to perfluorooctanoic acid induces defects in prehatch and early posthatch development
AU - Yanai, Joseph
AU - Dotan, Sharon
AU - Goz, Roman
AU - Pinkas, Adi
AU - Seidler, Frederic J.
AU - Slotkin, Theodore A.
AU - Zimmerman, Frederic
N1 - Funding Information:
Research was supported by National Institutes of Health grant ES14358. The authors state that they have no conflicts of interest. Theodore Slotkin and Frederic Seidler have provided expert witness testimony on behalf of governmental agencies, corporations, and/or individuals.
PY - 2008/1
Y1 - 2008/1
N2 - There is increasing concern over the widespread use of perfluorinated chemicals, which accumulate in various tissues and penetrate the mammalian fetus. A chick model was established for the rapid evaluation of teratogenicity of these chemicals, an important issue because developmental defects often occur at lower exposures than those required for adult systemic toxicity. Chicken eggs were injected with varying doses of perfluorooctanoic acid prior to incubation. Observed were defects in hatching, increased incidence of splayed legs, and interference with the appropriate development of yellow plumage. All these defects are potentially related to essential molecular/biochemical and functional development of the chick. Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses.
AB - There is increasing concern over the widespread use of perfluorinated chemicals, which accumulate in various tissues and penetrate the mammalian fetus. A chick model was established for the rapid evaluation of teratogenicity of these chemicals, an important issue because developmental defects often occur at lower exposures than those required for adult systemic toxicity. Chicken eggs were injected with varying doses of perfluorooctanoic acid prior to incubation. Observed were defects in hatching, increased incidence of splayed legs, and interference with the appropriate development of yellow plumage. All these defects are potentially related to essential molecular/biochemical and functional development of the chick. Because of the relationship between structural defects and vulnerability of the developing brain, our model points to the need to evaluate neurobehavioral teratogenicity, which may involve even lower doses.
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U2 - 10.1080/15287390701613280
DO - 10.1080/15287390701613280
M3 - Article
C2 - 18080903
AN - SCOPUS:37249008709
SN - 1528-7394
VL - 71
SP - 131
EP - 133
JO - Journal of Toxicology and Environmental Health - Part A: Current Issues
JF - Journal of Toxicology and Environmental Health - Part A: Current Issues
IS - 2
ER -