Exposure, epidemiology, and mechanism of the environmental toxicant manganese

Pan Chen, Megan Culbreth, Michael Aschner

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

It has become increasingly apparent that global manganese (Mn) pollution to air and water is a significant threat to human health. Despite this recognition, research is only beginning to comprehend the detrimental effects of exposure. Mn, while essential, is particularly harmful to the central nervous system, and overexposure is symptomatic of several neurological disorders. At-risk populations have been identified, but it is still unclear whether typical exposure levels have any long-term consequences. Those at an elevated risk have diminished intellectual function, learning and memory, and mental development. While the overall mechanism of toxicity is undetermined, Mn has been found to induce oxidative stress, exacerbate mitochondrial dysfunction, dysregulate autophagy, and promote apoptosis, ultimately enhancing neurodegeneration. Extrapolation of this in vitro and in vivo data to humans is difficult. There is a definite need to correlate epidemiological studies with causative effects. It is imperative that research efforts endure, so threats are appropriately identified and exposure properly regulated.

Original languageEnglish (US)
Pages (from-to)1-9
Number of pages9
JournalEnvironmental Science and Pollution Research
DOIs
StateAccepted/In press - Apr 22 2016

Fingerprint

Epidemiology
epidemiology
Manganese
manganese
Water Pollution
Oxidative stress
Air Pollution
Autophagy
apoptosis
Neurology
Cell death
nervous system
Nervous System Diseases
Research
Extrapolation
Toxicity
Epidemiologic Studies
Oxidative Stress
Pollution
Central Nervous System

Keywords

  • Developmental
  • Manganese
  • Mechanisms
  • Neurotoxicity

ASJC Scopus subject areas

  • Environmental Chemistry
  • Health, Toxicology and Mutagenesis
  • Pollution

Cite this

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