Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis

Marta Del Valle Rubido, Eric Hollander, James T. McCracken, Frederick Shic, Jana Noeldeke, Lauren Boak, Omar Khwaja, Shamil Sadikhov, Paulo Fontoura, Daniel Umbricht

Research output: Contribution to journalArticle

Abstract

Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018). Our preliminary results suggest the potential use for stratification and response sub-analyses outcome-prediction of specific eye-tracking tasks, pupillometry and olfaction tests in ASD trials.

Original languageEnglish (US)
JournalJournal of Autism and Developmental Disorders
DOIs
StateAccepted/In press - Jan 1 2020

Keywords

  • Biomarker
  • Eye movement
  • Olfactory
  • Social cognition

ASJC Scopus subject areas

  • Developmental and Educational Psychology

Fingerprint Dive into the research topics of 'Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis'. Together they form a unique fingerprint.

  • Cite this