Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis

Marta Del Valle Rubido; Eric Hollander; James T. McCracken; Frederick Shic; Jana Noeldeke; Lauren Boak; Omar Khwaja; Shamil Sadikhov; Paulo Fontoura; Daniel Umbricht

doi:10.1007/s10803-020-04493-5

Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis

Marta Del Valle Rubido, Eric Hollander, James T. McCracken, Frederick Shic, Jana Noeldeke, Lauren Boak, Omar Khwaja, Shamil Sadikhov, Paulo Fontoura, Daniel Umbricht

Psychiatry and Behavioral Sciences

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018).

Original language	English (US)
Pages (from-to)	4412-4430
Number of pages	19
Journal	Journal of Autism and Developmental Disorders
Volume	50
Issue number	12
DOIs	https://doi.org/10.1007/s10803-020-04493-5
State	Published - Dec 2020

Keywords

Biomarker
Eye movement
Olfactory
Social cognition

ASJC Scopus subject areas

Developmental and Educational Psychology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s10803-020-04493-5

Cite this

Del Valle Rubido, M., Hollander, E., McCracken, J. T., Shic, F., Noeldeke, J., Boak, L., Khwaja, O., Sadikhov, S., Fontoura, P., & Umbricht, D. (2020). Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis. Journal of Autism and Developmental Disorders, 50(12), 4412-4430. https://doi.org/10.1007/s10803-020-04493-5

Del Valle Rubido, M, Hollander, E, McCracken, JT, Shic, F, Noeldeke, J, Boak, L, Khwaja, O, Sadikhov, S, Fontoura, P & Umbricht, D 2020, 'Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis', Journal of Autism and Developmental Disorders, vol. 50, no. 12, pp. 4412-4430. https://doi.org/10.1007/s10803-020-04493-5

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abstract = "Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018).",

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note = "Funding Information: The studies were funded by F. Hoffmann-La Roche. Medical writing and editing services were provided by Watermeadow Medical, an Ashfield Company, part of UDG Healthcare plc, funded by F. Hoffmann-La Roche. Acknowledgments Publisher Copyright: {\textcopyright} 2020, The Author(s).",

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doi = "10.1007/s10803-020-04493-5",

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AU - Noeldeke, Jana

AU - Boak, Lauren

AU - Khwaja, Omar

AU - Sadikhov, Shamil

AU - Fontoura, Paulo

AU - Umbricht, Daniel

N1 - Funding Information: The studies were funded by F. Hoffmann-La Roche. Medical writing and editing services were provided by Watermeadow Medical, an Ashfield Company, part of UDG Healthcare plc, funded by F. Hoffmann-La Roche. Acknowledgments Publisher Copyright: © 2020, The Author(s).

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AB - Biomarkers for autism spectrum disorder (ASD) are lacking but would facilitate drug development for the core deficits of the disorder. We evaluated markers proposed for characterization of differences in social communication and interaction in adults with ASD versus healthy controls (HC) for utility as biomarkers. Data pooled from an observational study and baseline data from a placebo-controlled study were analyzed. Between-group differences were observed in eye-tracking tasks for activity monitoring, biomotion, human activity preference, composite score (p = 0.0001–0.037) and pupillometry (various tasks, p = 0.017–0.05). Impaired olfaction was more common in the ASD sample versus HC (p = 0.018).

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Exploring Social Biomarkers in High-Functioning Adults with Autism and Asperger’s Versus Healthy Controls: A Cross-Sectional Analysis

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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