Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Samuel J. Taylor, Sriram Sundaravel, Ulrich Steidl

Research output: Contribution to journalArticlepeer-review

Abstract

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

Original languageEnglish (US)
Pages (from-to)3445-3446
Number of pages2
JournalMolecular Cell
Volume81
Issue number17
DOIs
StatePublished - Sep 2 2021

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology

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