Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Samuel J. Taylor; Sriram Sundaravel; Ulrich Steidl

doi:10.1016/j.molcel.2021.08.013

Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Samuel J. Taylor, Sriram Sundaravel, Ulrich Steidl

Cell Biology

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1 Scopus citations

Abstract

In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

Original language	English (US)
Pages (from-to)	3445-3446
Number of pages	2
Journal	Molecular Cell
Volume	81
Issue number	17
DOIs	https://doi.org/10.1016/j.molcel.2021.08.013
State	Published - Sep 2 2021

ASJC Scopus subject areas

Molecular Biology
Cell Biology

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10.1016/j.molcel.2021.08.013

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title = "Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML",

abstract = "In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.",

author = "Taylor, {Samuel J.} and Sriram Sundaravel and Ulrich Steidl",

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AU - Steidl, Ulrich

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AB - In this issue of Molecular Cell, Cao et al. (2021) report that AML cells are specifically addicted to an IRF8-MEF2D gene expression network. Furthermore, they identify a chromatin reader, ZMYND8, as the upstream regulator of the IRF8-MEF2D program whose activity is critical for AML cell survival.

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Exploiting a key transcriptional dependency: ZMYND8 and IRF8 in AML

Abstract

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