Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

Alyn H. Morice, Eva Millqvist, Maria G. Belvisi, Kristina Bieksiene, Surinder S. Birring, Kian F an Chung, Roberto W. Dal Negro, Peter Vytautas Dicpinigaitis, Ahmad Kantar, Lorcan P. McGarvey, Adalberto Pacheco, Raimundas Sakalauskas, Jaclyn A. Smith

Research output: Contribution to journalArticle

120 Citations (Scopus)

Abstract

In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions. There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough. The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.

Original languageEnglish (US)
Pages (from-to)1132-1148
Number of pages17
JournalEuropean Respiratory Journal
Volume44
Issue number5
DOIs
StatePublished - Nov 1 2014

Fingerprint

Pulmonary Medicine
Expert Testimony
Cough
Hypersensitivity
Advisory Committees
Hot Temperature
Steroids
Phenotype
Acids

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Morice, A. H., Millqvist, E., Belvisi, M. G., Bieksiene, K., Birring, S. S., Chung, K. F. A., ... Smith, J. A. (2014). Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. European Respiratory Journal, 44(5), 1132-1148. https://doi.org/10.1183/09031936.00218613

Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. / Morice, Alyn H.; Millqvist, Eva; Belvisi, Maria G.; Bieksiene, Kristina; Birring, Surinder S.; Chung, Kian F an; Dal Negro, Roberto W.; Dicpinigaitis, Peter Vytautas; Kantar, Ahmad; McGarvey, Lorcan P.; Pacheco, Adalberto; Sakalauskas, Raimundas; Smith, Jaclyn A.

In: European Respiratory Journal, Vol. 44, No. 5, 01.11.2014, p. 1132-1148.

Research output: Contribution to journalArticle

Morice, AH, Millqvist, E, Belvisi, MG, Bieksiene, K, Birring, SS, Chung, KFA, Dal Negro, RW, Dicpinigaitis, PV, Kantar, A, McGarvey, LP, Pacheco, A, Sakalauskas, R & Smith, JA 2014, 'Expert opinion on the cough hypersensitivity syndrome in respiratory medicine', European Respiratory Journal, vol. 44, no. 5, pp. 1132-1148. https://doi.org/10.1183/09031936.00218613
Morice AH, Millqvist E, Belvisi MG, Bieksiene K, Birring SS, Chung KFA et al. Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. European Respiratory Journal. 2014 Nov 1;44(5):1132-1148. https://doi.org/10.1183/09031936.00218613
Morice, Alyn H. ; Millqvist, Eva ; Belvisi, Maria G. ; Bieksiene, Kristina ; Birring, Surinder S. ; Chung, Kian F an ; Dal Negro, Roberto W. ; Dicpinigaitis, Peter Vytautas ; Kantar, Ahmad ; McGarvey, Lorcan P. ; Pacheco, Adalberto ; Sakalauskas, Raimundas ; Smith, Jaclyn A. / Expert opinion on the cough hypersensitivity syndrome in respiratory medicine. In: European Respiratory Journal. 2014 ; Vol. 44, No. 5. pp. 1132-1148.
@article{de8576c1774644ceb7f68ebd59ddb977,
title = "Expert opinion on the cough hypersensitivity syndrome in respiratory medicine",
abstract = "In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions. There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough. The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.",
author = "Morice, {Alyn H.} and Eva Millqvist and Belvisi, {Maria G.} and Kristina Bieksiene and Birring, {Surinder S.} and Chung, {Kian F an} and {Dal Negro}, {Roberto W.} and Dicpinigaitis, {Peter Vytautas} and Ahmad Kantar and McGarvey, {Lorcan P.} and Adalberto Pacheco and Raimundas Sakalauskas and Smith, {Jaclyn A.}",
year = "2014",
month = "11",
day = "1",
doi = "10.1183/09031936.00218613",
language = "English (US)",
volume = "44",
pages = "1132--1148",
journal = "European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "5",

}

TY - JOUR

T1 - Expert opinion on the cough hypersensitivity syndrome in respiratory medicine

AU - Morice, Alyn H.

AU - Millqvist, Eva

AU - Belvisi, Maria G.

AU - Bieksiene, Kristina

AU - Birring, Surinder S.

AU - Chung, Kian F an

AU - Dal Negro, Roberto W.

AU - Dicpinigaitis, Peter Vytautas

AU - Kantar, Ahmad

AU - McGarvey, Lorcan P.

AU - Pacheco, Adalberto

AU - Sakalauskas, Raimundas

AU - Smith, Jaclyn A.

PY - 2014/11/1

Y1 - 2014/11/1

N2 - In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions. There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough. The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.

AB - In 2011, a European Respiratory Society Task Force embarked on a process to determine the position and clinical relevance of the cough hypersensitivity syndrome, a disorder characterised by troublesome coughing often triggered by low levels of thermal, mechanical or chemical exposure, in the management of patients with chronic cough. A 21-component questionnaire was developed by an iterative process supported by a literature review. 44 key opinion leaders in respiratory medicine were selected and interviewed as to their opinions. There was a high degree of unanimity in the responses obtained, with all opinion leaders supporting the concept of cough hypersensitivity as a clinically useful paradigm. The classic stratification of cough into asthmatic, rhinitic and reflux-related phenotypes was supported. Significant disparity of opinion was seen in the response to two questions concerning the therapy of chronic cough. First, the role of acid suppression in reflux cough was questioned. Secondly, the opinion leaders were split as to whether a trial of oral steroids was indicated to establish a diagnosis of eosinophilic cough. The cough hypersensitivity syndrome was clearly endorsed by the opinion leaders as a valid and useful concept. They considered that support of patients with chronic cough was inadequate and the Task Force recommends that further work is urgently required in this neglected area.

UR - http://www.scopus.com/inward/record.url?scp=84965184104&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84965184104&partnerID=8YFLogxK

U2 - 10.1183/09031936.00218613

DO - 10.1183/09031936.00218613

M3 - Article

C2 - 25142479

AN - SCOPUS:84965184104

VL - 44

SP - 1132

EP - 1148

JO - European Respiratory Journal

JF - European Respiratory Journal

SN - 0903-1936

IS - 5

ER -