Experimental spinal cord injury: Treatment with naloxone

E. S. Flamm, W. Young, H. B. Demopoulos, V. DeCrescito, J. J. Tomasula

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

We studied the effect of the opiate antagonist naloxone on the recovery of cats injured with a 400-g-cm impact injury to T-9. The animals were evaluated by recording somatosensory evoked potentials and performing weekly neurological examinations. Several dose schedules were followed. Six of eight cats that received an intravenous or intraperitoneal bolus of naloxone (10 mg/kg) 45 minutes after injury regained the ability to walk. Recovery occurred in only one of five animals that were treated with an infusion of naloxone, 10 mg/kg/hour, and in none of five animals given 1 mg/kg as a bolus. Because these results are not related to any observed change in blood pressure, we believe that naloxone may be achieving its effect through the preservation of spinal cord blood flow, as well as other mechanisms that have yet to be defined.

Original languageEnglish (US)
Pages (from-to)227-231
Number of pages5
JournalUnknown Journal
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1982
Externally publishedYes

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology

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    Flamm, E. S., Young, W., Demopoulos, H. B., DeCrescito, V., & Tomasula, J. J. (1982). Experimental spinal cord injury: Treatment with naloxone. Unknown Journal, 10(2), 227-231. https://doi.org/10.1227/00006123-198202000-00009