Abstract
Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 239-243 |
| Number of pages | 5 |
| Journal | Investigative Radiology |
| Volume | 10 |
| Issue number | 3 |
| State | Published - 1975 |
| Externally published | Yes |
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Keywords
- C-AMP
- Cerebral vasospasm
- Isoproterenol
- Phosphodiesterase inhibitor
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging
- Radiological and Ultrasound Technology
Cite this
Experimental cerebral vasospasm and cyclic adenosine monophosphate (C-amp). / Kim, Jhinho; Flamm, Eugene S.; Lin, Joseph.
In: Investigative Radiology, Vol. 10, No. 3, 1975, p. 239-243.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Experimental cerebral vasospasm and cyclic adenosine monophosphate (C-amp)
AU - Kim, Jhinho
AU - Flamm, Eugene S.
AU - Lin, Joseph
PY - 1975
Y1 - 1975
N2 - Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.
AB - Blood induced acute and chronic cerebral vasospasm were studied in Rhesus monkeys by serial angiography. Two vasoactive agents were evaluated. In acute spasm, phosphodiesterase inhibition by Aminophylline consistently reversed the vasospasm. This agent alone was ineffective in chronic spasm and required the addition of Isoproterenol to produce reversal of vasospasm. It is proposed that cerebral vasospasm may be associated with a decrease of intracellular c-AMP in vascular smooth muscle which can be reversed by manipulation of the enzyme pathway involved. It is further proposed that c-AMP is a basic common pathway through which adrenergic vascular reactivities are mediated.
KW - C-AMP
KW - Cerebral vasospasm
KW - Isoproterenol
KW - Phosphodiesterase inhibitor
UR - http://www.scopus.com/inward/record.url?scp=0016760805&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0016760805&partnerID=8YFLogxK
M3 - Article
C2 - 166052
AN - SCOPUS:0016760805
VL - 10
SP - 239
EP - 243
JO - Investigative Radiology
JF - Investigative Radiology
SN - 0020-9996
IS - 3
ER -