Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery

Eugene S. Flamm, Anna T. Viau, Joseph Ransohoff, N. Eric Naftchi

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Levels of cyclic adenosine monophosphate (AMP) in the basilar artery and in circulating blood of cats were determined after the production of spasm by topical application of blood to the vessel and following treatment with agents known to alter cyclic AMP. Isoproterenol, known to stimulate adenyl cyclase, and aminophylline, a phosphodiesterase inhibitor, were studied alone and in combination. Cyclic AMP of the basilar artery fell from a mean control value of 43 to 26 pmoles per milligram of protein following the production of vasospasm. Intravenous administration of isoproterenol alone and in combination with aminophylline produced dilatation of the basilar artery, which was associated with a marked rise in the cyclic AMP concentration in the vessel. The finding that cerebral vasospasm is associated with a fall and vasodilatation with a rise in cyclic AMP concentration supports the hypothesis of an active role for cyclic nucleotides in the regulation of cerebrovascular smooth muscle tone.

Original languageEnglish (US)
Pages (from-to)664-666
Number of pages3
JournalNeurology
Volume26
Issue number7
StatePublished - 1976
Externally publishedYes

Fingerprint

Basilar Artery
Cyclic AMP
Cats
Aminophylline
Isoproterenol
Intracranial Vasospasm
Phosphodiesterase Inhibitors
Cyclic Nucleotides
Spasm
Adenylyl Cyclases
Vasodilation
Intravenous Administration
Smooth Muscle
Blood Vessels
Dilatation
Alteration
Proteins

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery. / Flamm, Eugene S.; Viau, Anna T.; Ransohoff, Joseph; Naftchi, N. Eric.

In: Neurology, Vol. 26, No. 7, 1976, p. 664-666.

Research output: Contribution to journalArticle

Flamm, ES, Viau, AT, Ransohoff, J & Naftchi, NE 1976, 'Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery', Neurology, vol. 26, no. 7, pp. 664-666.
Flamm, Eugene S. ; Viau, Anna T. ; Ransohoff, Joseph ; Naftchi, N. Eric. / Experimental alterations in cyclic adenosine monophosphate concentrations in the cat basilar artery. In: Neurology. 1976 ; Vol. 26, No. 7. pp. 664-666.
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