Exercising the hepatobiliary-gut axis. The impact of physical activity performance

Emilio Molina-Molina, Raquel Lunardi Baccetto, David Q.H. Wang, Ornella de Bari, Marcin Krawczyk, Piero Portincasa

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Background: Physical inactivity puts the populations at risk of several health problems, while regular physical activity brings beneficial effects on cardiovascular disease, mortality and other health outcomes, including obesity, glycaemic control and insulin resistance. The hepatobiliary tract is greatly involved in several metabolic aspects which include digestion and absorption of nutrients in concert with intestinal motility, bile acid secretion and flow across the enterohepatic circulation and intestinal microbiota. Several metabolic abnormalities, including nonalcoholic fatty liver as well as cholesterol cholelithiasis, represent two conditions explained by changes of the aforementioned pathways. Materials and Methods: This review defines different training modalities and discusses the effects of physical activity in two metabolic disorders, that is nonalcoholic fatty liver disease (NAFLD) and cholelithiasis. Emphasis is given to pathogenic mechanisms involving intestinal bile acids, microbiota and inflammatory status. Results: A full definition of physical activity includes the knowledge of aerobic and endurance exercise, metabolic equivalent tasks, duration, frequency and intensity, beneficial and harmful effects. Physical activity influences the hepatobiliary-gut axis at different levels and brings benefits to fat distribution, liver fat and gallbladder disease while interacting with bile acids as signalling molecules, intestinal microbiota and inflammatory changes in the body. Conclusions: Several beneficial effects of physical activity are anticipated on metabolic disorders linking liver steatosis, gallstone disease, gut motility, enterohepatic circulation of signalling bile acids in relation to intestinal microbiota and inflammatory changes.

Original languageEnglish (US)
Article numbere12958
JournalEuropean Journal of Clinical Investigation
Volume48
Issue number8
DOIs
StatePublished - Aug 1 2018

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Bile Acids and Salts
Liver
Enterohepatic Circulation
Cholelithiasis
Fats
Metabolic Equivalent
Gallbladder Diseases
Gastrointestinal Motility
Microbiota
Health
Gallstones
Fatty Liver
Medical problems
Nutrients
Insulin Resistance
Liver Diseases
Digestion
Durability
Cardiovascular Diseases
Obesity

Keywords

  • bile acids
  • farnesoid X receptor
  • G protein–coupled bile acid receptor-1
  • gallstone disease
  • gut microbiota
  • nonalcoholic fatty liver disease

ASJC Scopus subject areas

  • Biochemistry
  • Clinical Biochemistry

Cite this

Exercising the hepatobiliary-gut axis. The impact of physical activity performance. / Molina-Molina, Emilio; Lunardi Baccetto, Raquel; Wang, David Q.H.; de Bari, Ornella; Krawczyk, Marcin; Portincasa, Piero.

In: European Journal of Clinical Investigation, Vol. 48, No. 8, e12958, 01.08.2018.

Research output: Contribution to journalReview article

Molina-Molina, E, Lunardi Baccetto, R, Wang, DQH, de Bari, O, Krawczyk, M & Portincasa, P 2018, 'Exercising the hepatobiliary-gut axis. The impact of physical activity performance', European Journal of Clinical Investigation, vol. 48, no. 8, e12958. https://doi.org/10.1111/eci.12958
Molina-Molina, Emilio ; Lunardi Baccetto, Raquel ; Wang, David Q.H. ; de Bari, Ornella ; Krawczyk, Marcin ; Portincasa, Piero. / Exercising the hepatobiliary-gut axis. The impact of physical activity performance. In: European Journal of Clinical Investigation. 2018 ; Vol. 48, No. 8.
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