Exercise Renography in Untreated Subjects with Essential Hypertension

Eugene J. Fine, M. Donald Blaufox, Jon D. Blumenfeld, John H. Laragh, Kwang J. Chun, Sherman L. Heller, Josephine A. Bongiovanni

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Exercise induced renal dysfunction is reported to occur in treated hypertensive patients but not seen normotensive subjects. It is unclear if this phenomenon is related to the disease or to treatment. Methods: Four normal volunteers and 15 hypertensive subjects (antihypertensive medications were discontinued for more than 4 wk) were studied with upright radionuclide renography at rest and during bicycle exercise. The amount of exercise was sufficient to increase the heart rate at least 20 bpm above the resting value. All subjects were healthy, without evidence of left ventricular hypertrophy renal disease or hypertensive retinal disease. BUN, serum creatinine concentration and urinalysis were normal in all subjects. Renograms were performed for 12-15 min after injection of either 1 mCi [123|]orthoiodohippurate (OIH) or 2-7 mCi 99mTc-mercaptoacetyltriglycine (MAG3). Visual analysis and mean transit time calculation were performed on the rest and exercise studies. Results: Seven of 14 hypertensive subjects and none of the normal volunteers demonstrated abnormal prolongation in renal transit during exercise which was not seen on the resting renogram. Four of these seven subjects had a history of hypertension for 2 yr or less. Conclusion: About 50% of individuals with mild-to-moderate hypertension and normal renal function may have abnormal renal transit of renal excretion agents during exercise, although their baseline studies are normal. This finding is unassociated with therapy and appears to be related directly to the pathophysiology of essential hypertension.

Original languageEnglish (US)
Pages (from-to)838-842
Number of pages5
JournalJournal of Nuclear Medicine
Volume37
Issue number5
StatePublished - 1996
Externally publishedYes

Fingerprint

Radioisotope Renography
Exercise
Technetium Tc 99m Mertiatide
Kidney
Healthy Volunteers
Iodohippuric Acid
Renal Agents
Retinal Diseases
Renal Hypertension
Urinalysis
Blood Urea Nitrogen
Left Ventricular Hypertrophy
Radioisotopes
Antihypertensive Agents
Essential Hypertension
Creatinine
Heart Rate
Hypertension
Injections
Therapeutics

Keywords

  • Iodine-123-OIH
  • Renal circulation
  • Renal hypertension
  • Technetium99m-MAG3

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Fine, E. J., Blaufox, M. D., Blumenfeld, J. D., Laragh, J. H., Chun, K. J., Heller, S. L., & Bongiovanni, J. A. (1996). Exercise Renography in Untreated Subjects with Essential Hypertension. Journal of Nuclear Medicine, 37(5), 838-842.

Exercise Renography in Untreated Subjects with Essential Hypertension. / Fine, Eugene J.; Blaufox, M. Donald; Blumenfeld, Jon D.; Laragh, John H.; Chun, Kwang J.; Heller, Sherman L.; Bongiovanni, Josephine A.

In: Journal of Nuclear Medicine, Vol. 37, No. 5, 1996, p. 838-842.

Research output: Contribution to journalArticle

Fine, EJ, Blaufox, MD, Blumenfeld, JD, Laragh, JH, Chun, KJ, Heller, SL & Bongiovanni, JA 1996, 'Exercise Renography in Untreated Subjects with Essential Hypertension', Journal of Nuclear Medicine, vol. 37, no. 5, pp. 838-842.
Fine EJ, Blaufox MD, Blumenfeld JD, Laragh JH, Chun KJ, Heller SL et al. Exercise Renography in Untreated Subjects with Essential Hypertension. Journal of Nuclear Medicine. 1996;37(5):838-842.
Fine, Eugene J. ; Blaufox, M. Donald ; Blumenfeld, Jon D. ; Laragh, John H. ; Chun, Kwang J. ; Heller, Sherman L. ; Bongiovanni, Josephine A. / Exercise Renography in Untreated Subjects with Essential Hypertension. In: Journal of Nuclear Medicine. 1996 ; Vol. 37, No. 5. pp. 838-842.
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