This chapter explores mechanisms associated with organophosphates (OP) induced neurotoxicity by probing their effects on oxidative stress and associated dendritic degeneration of pyramidal neurons in the CA1 hippocampal area. It also investigates different pathways to attenuate biomarkers of oxidative damage associated with anticholinesterase exposure and the extent to which such attenuation is accompanied by rescue from neurodegeneration. Exposure to OP nerve agents induces seizures, rapidly progressing to status epilepticus and profound structural brain damage. The progression of events includes initial high cholinergic activity followed by activation of glutamatergic neurons as a result of release of glutamate. Moreover, glutamate stimulates the continuous release of ACh, contributing to further excitatory stimulation, prolongation of the seizures, and excitotoxic neurodegeneration in vulnerable brain areas. The ensuing neuronal damage is thought to result from intense transient influx of calcium leading to mitochondrial functional impairment, cytochrome c inactivation, depletion of ATP, simultaneous formation of free radical species, and oxidative stress. Among promising candidates as antidotes against CNS intoxication by OP nerve agents, memantine (MEM) has been shown to pose both antiexcitotoxic and antiepileptic properties. Memantine is an uncompetitive NMDA receptor antagonist, clinically used for the treatment of Alzheimer's disease, Parkinson's disease, and spasticity, in the absence of serious side effects.
ASJC Scopus subject areas
- Pharmacology, Toxicology and Pharmaceutics(all)