Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe

Yuhua Shang, Adam Claridge-Chang, Lucas L. Sjulson, Marc Pypaert, Gero Miesenböck

Research output: Contribution to journalArticle

225 Citations (Scopus)

Abstract

Conflicting views exist of how circuits of the antennal lobe, the insect equivalent of the olfactory bulb, translate input from olfactory receptor neurons (ORNs) into projection-neuron (PN) output. Synaptic connections between ORNs and PNs are one-to-one, yet PNs are more broadly tuned to odors than ORNs. The basis for this difference in receptive range remains unknown. Analyzing a Drosophila mutant lacking ORN input to one glomerulus, we show that some of the apparent complexity in the antennal lobe's output arises from lateral, interglomerular excitation of PNs. We describe a previously unidentified population of cholinergic local neurons (LNs) with multiglomerular processes. These excitatory LNs respond broadly to odors but exhibit little glomerular specificity in their synaptic output, suggesting that PNs are driven by a combination of glomerulus-specific ORN afferents and diffuse LN excitation. Lateral excitation may boost PN signals and enhance their transmission to third-order neurons in a mechanism akin to stochastic resonance.

Original languageEnglish (US)
Pages (from-to)601-612
Number of pages12
JournalCell
Volume128
Issue number3
DOIs
StatePublished - Feb 9 2007
Externally publishedYes

Fingerprint

Olfactory Receptor Neurons
Neurons
Odorant Receptors
Networks (circuits)
Processing
Cholinergic Neurons
Olfactory Bulb
Odors
Drosophila
Insects
Population
Cholinergic Agents

ASJC Scopus subject areas

  • Cell Biology
  • Molecular Biology

Cite this

Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe. / Shang, Yuhua; Claridge-Chang, Adam; Sjulson, Lucas L.; Pypaert, Marc; Miesenböck, Gero.

In: Cell, Vol. 128, No. 3, 09.02.2007, p. 601-612.

Research output: Contribution to journalArticle

Shang, Yuhua ; Claridge-Chang, Adam ; Sjulson, Lucas L. ; Pypaert, Marc ; Miesenböck, Gero. / Excitatory Local Circuits and Their Implications for Olfactory Processing in the Fly Antennal Lobe. In: Cell. 2007 ; Vol. 128, No. 3. pp. 601-612.
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