Exceptional Parental longevity associated with lower risk of alzheimer's disease and memory decline

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Abstract

Objectives: To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). Design: Community-based prospective cohort study. Setting: Bronx, New York. Participants: A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting in 1980 and followed for up to 23 years. Measurements: Epidemiological, clinical, and neuropsychological assessments were completed every 12 to 18 months. OPEL were defined as having at least one parent who reached the age of at least 85. OPUS were those for whom neither parent reached the age of 85. Dementia was diagnosed according to case conference consensus based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, criteria without access to information on parental longevity. Alzheimer's disease was diagnosed using established criteria. Results: Of 424 subjects, 149 (35%) were OPEL, and 275 (65%) were OPUS. Mean age at entry for both groups was 79. The OPEL group had a lower incidence of Alzheimer's disease (hazard ratio=0.57, 95% confidence interval=0.35-0.93). After adjusting for sex, education, race, hypertension, myocardial infarction, diabetes mellitus, and stroke, results were essentially unchanged. OPEL also had a significantly lower rate of memory decline on the Selective Reminding Test (SRT) than OPUS (P=.03). Conclusion: OPEL develop dementia and Alzheimer's disease at a significantly lower rate than OPUS. Demographic and medical confounders do not explain this result. Factors associated with longevity may protect against dementia and Alzheimer's disease.

Original languageEnglish (US)
Pages (from-to)1043-1049
Number of pages7
JournalJournal of the American Geriatrics Society
Volume58
Issue number6
DOIs
StatePublished - Jun 2010

Fingerprint

Alzheimer Disease
Parents
Dementia
Survival
Access to Information
Sex Education
Diagnostic and Statistical Manual of Mental Disorders
Volunteers
Consensus
Diabetes Mellitus
Cohort Studies
Stroke
Myocardial Infarction
Demography
Prospective Studies
Confidence Intervals
Hypertension
Incidence

Keywords

  • Alzheimer's disease
  • Dementia
  • Memory decline
  • Parental longevity

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Medicine(all)

Cite this

@article{ba1ce57143db4d7096d3702f120b9978,
title = "Exceptional Parental longevity associated with lower risk of alzheimer's disease and memory decline",
abstract = "Objectives: To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). Design: Community-based prospective cohort study. Setting: Bronx, New York. Participants: A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting in 1980 and followed for up to 23 years. Measurements: Epidemiological, clinical, and neuropsychological assessments were completed every 12 to 18 months. OPEL were defined as having at least one parent who reached the age of at least 85. OPUS were those for whom neither parent reached the age of 85. Dementia was diagnosed according to case conference consensus based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, criteria without access to information on parental longevity. Alzheimer's disease was diagnosed using established criteria. Results: Of 424 subjects, 149 (35{\%}) were OPEL, and 275 (65{\%}) were OPUS. Mean age at entry for both groups was 79. The OPEL group had a lower incidence of Alzheimer's disease (hazard ratio=0.57, 95{\%} confidence interval=0.35-0.93). After adjusting for sex, education, race, hypertension, myocardial infarction, diabetes mellitus, and stroke, results were essentially unchanged. OPEL also had a significantly lower rate of memory decline on the Selective Reminding Test (SRT) than OPUS (P=.03). Conclusion: OPEL develop dementia and Alzheimer's disease at a significantly lower rate than OPUS. Demographic and medical confounders do not explain this result. Factors associated with longevity may protect against dementia and Alzheimer's disease.",
keywords = "Alzheimer's disease, Dementia, Memory decline, Parental longevity",
author = "Lipton, {Richard B.} and Jamie Hirsch and Katz, {Mindy Joy} and Cuiling Wang and Sanders, {Amy E.} and Joe Verghese and Nir Barzilai and Derby, {Carol A.}",
year = "2010",
month = "6",
doi = "10.1111/j.1532-5415.2010.02868.x",
language = "English (US)",
volume = "58",
pages = "1043--1049",
journal = "Journal of the American Geriatrics Society",
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TY - JOUR

T1 - Exceptional Parental longevity associated with lower risk of alzheimer's disease and memory decline

AU - Lipton, Richard B.

AU - Hirsch, Jamie

AU - Katz, Mindy Joy

AU - Wang, Cuiling

AU - Sanders, Amy E.

AU - Verghese, Joe

AU - Barzilai, Nir

AU - Derby, Carol A.

PY - 2010/6

Y1 - 2010/6

N2 - Objectives: To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). Design: Community-based prospective cohort study. Setting: Bronx, New York. Participants: A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting in 1980 and followed for up to 23 years. Measurements: Epidemiological, clinical, and neuropsychological assessments were completed every 12 to 18 months. OPEL were defined as having at least one parent who reached the age of at least 85. OPUS were those for whom neither parent reached the age of 85. Dementia was diagnosed according to case conference consensus based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, criteria without access to information on parental longevity. Alzheimer's disease was diagnosed using established criteria. Results: Of 424 subjects, 149 (35%) were OPEL, and 275 (65%) were OPUS. Mean age at entry for both groups was 79. The OPEL group had a lower incidence of Alzheimer's disease (hazard ratio=0.57, 95% confidence interval=0.35-0.93). After adjusting for sex, education, race, hypertension, myocardial infarction, diabetes mellitus, and stroke, results were essentially unchanged. OPEL also had a significantly lower rate of memory decline on the Selective Reminding Test (SRT) than OPUS (P=.03). Conclusion: OPEL develop dementia and Alzheimer's disease at a significantly lower rate than OPUS. Demographic and medical confounders do not explain this result. Factors associated with longevity may protect against dementia and Alzheimer's disease.

AB - Objectives: To determine whether offspring of parents with exceptional longevity (OPEL) have a lower rate of dementia than offspring of parents with usual survival (OPUS). Design: Community-based prospective cohort study. Setting: Bronx, New York. Participants: A volunteer sample of 424 community-residing older adults without dementia aged 75 to 85 recruited from Bronx County starting in 1980 and followed for up to 23 years. Measurements: Epidemiological, clinical, and neuropsychological assessments were completed every 12 to 18 months. OPEL were defined as having at least one parent who reached the age of at least 85. OPUS were those for whom neither parent reached the age of 85. Dementia was diagnosed according to case conference consensus based on Diagnostic and Statistical Manual of Mental Disorders, Third Edition, Revised, criteria without access to information on parental longevity. Alzheimer's disease was diagnosed using established criteria. Results: Of 424 subjects, 149 (35%) were OPEL, and 275 (65%) were OPUS. Mean age at entry for both groups was 79. The OPEL group had a lower incidence of Alzheimer's disease (hazard ratio=0.57, 95% confidence interval=0.35-0.93). After adjusting for sex, education, race, hypertension, myocardial infarction, diabetes mellitus, and stroke, results were essentially unchanged. OPEL also had a significantly lower rate of memory decline on the Selective Reminding Test (SRT) than OPUS (P=.03). Conclusion: OPEL develop dementia and Alzheimer's disease at a significantly lower rate than OPUS. Demographic and medical confounders do not explain this result. Factors associated with longevity may protect against dementia and Alzheimer's disease.

KW - Alzheimer's disease

KW - Dementia

KW - Memory decline

KW - Parental longevity

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JO - Journal of the American Geriatrics Society

JF - Journal of the American Geriatrics Society

SN - 0002-8614

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