Excellent outcome using "impaired" standard criteria donors with elevated serum creatinine

Stuart M. Greenstein, Norman Moore, Patricia Mcdonough, Richard Schechner, Vivian Tellis

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: To maximize organ utilization, the United Network for Organ Sharing (UNOS) encourages use of Expanded Criteria Donors (ECD). However, Standard Criteria Donors (SCD) may also be under-utilized, some centers discarding kidneys with serum creatinine (S.Cr) >2.0 at nephrectomy. Our experience with the use of such "impaired" kidneys was reviewed retrospectively. Results: From January 1, 2003 to October 1, 2006, of 130 DD kidneys transplanted at our center, 26 were ECD. Also, 22 kidneys were from Impaired SCD (ISCD), with mean S.Cr 3.2 (2.1-4.4) at nephrectomy; eight of these had S.Cr >4.0. For these 22 ISCD, mean age was 22 yrs (11-42), sex: 16 Males; race:12 Caucasians/10 African-Americans; All had evidence of rhabdomyolysis (Mean peak CPK 11,924 u/l). Thirty-seven percent came from outside OPOs. Recipient demographics: age 45 years; sex 50% male, 45% African-American. Mean HLA match was 1; dialysis was required in 28% within the first week. Mean length of stay was 10.7 days. Average discharge S.Cr was 4.2. All kidneys are currently functioning (S.Cr at 3 months, 6 months and 1 year 1.6, 1.7 and 1.7 respectively). Conclusion: An elevated creatinine should not be the only cause for discarding deceased donor kidneys.

Original languageEnglish (US)
Pages (from-to)630-633
Number of pages4
JournalClinical Transplantation
Volume22
Issue number5
DOIs
StatePublished - 2008

Fingerprint

Creatinine
Tissue Donors
Kidney
Serum
Nephrectomy
African Americans
Rhabdomyolysis
Dialysis
Length of Stay
Demography

Keywords

  • Creatinine
  • Donor
  • Extended
  • Kidney
  • Renal standard
  • Rhabdomyolysis

ASJC Scopus subject areas

  • Transplantation

Cite this

Excellent outcome using "impaired" standard criteria donors with elevated serum creatinine. / Greenstein, Stuart M.; Moore, Norman; Mcdonough, Patricia; Schechner, Richard; Tellis, Vivian.

In: Clinical Transplantation, Vol. 22, No. 5, 2008, p. 630-633.

Research output: Contribution to journalArticle

Greenstein, Stuart M. ; Moore, Norman ; Mcdonough, Patricia ; Schechner, Richard ; Tellis, Vivian. / Excellent outcome using "impaired" standard criteria donors with elevated serum creatinine. In: Clinical Transplantation. 2008 ; Vol. 22, No. 5. pp. 630-633.
@article{a14294e4c1734ad592d3023412d5c88b,
title = "Excellent outcome using {"}impaired{"} standard criteria donors with elevated serum creatinine",
abstract = "Introduction: To maximize organ utilization, the United Network for Organ Sharing (UNOS) encourages use of Expanded Criteria Donors (ECD). However, Standard Criteria Donors (SCD) may also be under-utilized, some centers discarding kidneys with serum creatinine (S.Cr) >2.0 at nephrectomy. Our experience with the use of such {"}impaired{"} kidneys was reviewed retrospectively. Results: From January 1, 2003 to October 1, 2006, of 130 DD kidneys transplanted at our center, 26 were ECD. Also, 22 kidneys were from Impaired SCD (ISCD), with mean S.Cr 3.2 (2.1-4.4) at nephrectomy; eight of these had S.Cr >4.0. For these 22 ISCD, mean age was 22 yrs (11-42), sex: 16 Males; race:12 Caucasians/10 African-Americans; All had evidence of rhabdomyolysis (Mean peak CPK 11,924 u/l). Thirty-seven percent came from outside OPOs. Recipient demographics: age 45 years; sex 50{\%} male, 45{\%} African-American. Mean HLA match was 1; dialysis was required in 28{\%} within the first week. Mean length of stay was 10.7 days. Average discharge S.Cr was 4.2. All kidneys are currently functioning (S.Cr at 3 months, 6 months and 1 year 1.6, 1.7 and 1.7 respectively). Conclusion: An elevated creatinine should not be the only cause for discarding deceased donor kidneys.",
keywords = "Creatinine, Donor, Extended, Kidney, Renal standard, Rhabdomyolysis",
author = "Greenstein, {Stuart M.} and Norman Moore and Patricia Mcdonough and Richard Schechner and Vivian Tellis",
year = "2008",
doi = "10.1111/j.1399-0012.2008.00835.x",
language = "English (US)",
volume = "22",
pages = "630--633",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Excellent outcome using "impaired" standard criteria donors with elevated serum creatinine

AU - Greenstein, Stuart M.

AU - Moore, Norman

AU - Mcdonough, Patricia

AU - Schechner, Richard

AU - Tellis, Vivian

PY - 2008

Y1 - 2008

N2 - Introduction: To maximize organ utilization, the United Network for Organ Sharing (UNOS) encourages use of Expanded Criteria Donors (ECD). However, Standard Criteria Donors (SCD) may also be under-utilized, some centers discarding kidneys with serum creatinine (S.Cr) >2.0 at nephrectomy. Our experience with the use of such "impaired" kidneys was reviewed retrospectively. Results: From January 1, 2003 to October 1, 2006, of 130 DD kidneys transplanted at our center, 26 were ECD. Also, 22 kidneys were from Impaired SCD (ISCD), with mean S.Cr 3.2 (2.1-4.4) at nephrectomy; eight of these had S.Cr >4.0. For these 22 ISCD, mean age was 22 yrs (11-42), sex: 16 Males; race:12 Caucasians/10 African-Americans; All had evidence of rhabdomyolysis (Mean peak CPK 11,924 u/l). Thirty-seven percent came from outside OPOs. Recipient demographics: age 45 years; sex 50% male, 45% African-American. Mean HLA match was 1; dialysis was required in 28% within the first week. Mean length of stay was 10.7 days. Average discharge S.Cr was 4.2. All kidneys are currently functioning (S.Cr at 3 months, 6 months and 1 year 1.6, 1.7 and 1.7 respectively). Conclusion: An elevated creatinine should not be the only cause for discarding deceased donor kidneys.

AB - Introduction: To maximize organ utilization, the United Network for Organ Sharing (UNOS) encourages use of Expanded Criteria Donors (ECD). However, Standard Criteria Donors (SCD) may also be under-utilized, some centers discarding kidneys with serum creatinine (S.Cr) >2.0 at nephrectomy. Our experience with the use of such "impaired" kidneys was reviewed retrospectively. Results: From January 1, 2003 to October 1, 2006, of 130 DD kidneys transplanted at our center, 26 were ECD. Also, 22 kidneys were from Impaired SCD (ISCD), with mean S.Cr 3.2 (2.1-4.4) at nephrectomy; eight of these had S.Cr >4.0. For these 22 ISCD, mean age was 22 yrs (11-42), sex: 16 Males; race:12 Caucasians/10 African-Americans; All had evidence of rhabdomyolysis (Mean peak CPK 11,924 u/l). Thirty-seven percent came from outside OPOs. Recipient demographics: age 45 years; sex 50% male, 45% African-American. Mean HLA match was 1; dialysis was required in 28% within the first week. Mean length of stay was 10.7 days. Average discharge S.Cr was 4.2. All kidneys are currently functioning (S.Cr at 3 months, 6 months and 1 year 1.6, 1.7 and 1.7 respectively). Conclusion: An elevated creatinine should not be the only cause for discarding deceased donor kidneys.

KW - Creatinine

KW - Donor

KW - Extended

KW - Kidney

KW - Renal standard

KW - Rhabdomyolysis

UR - http://www.scopus.com/inward/record.url?scp=52649141044&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=52649141044&partnerID=8YFLogxK

U2 - 10.1111/j.1399-0012.2008.00835.x

DO - 10.1111/j.1399-0012.2008.00835.x

M3 - Article

C2 - 18492072

AN - SCOPUS:52649141044

VL - 22

SP - 630

EP - 633

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 0902-0063

IS - 5

ER -