Evolvement of the treatment paradigm for metastatic colon cancer. From chemotherapy to targeted therapy

Santiago Aparo, Sanjay Goel

Research output: Contribution to journalReview article

11 Scopus citations

Abstract

Colorectal Cancer is the second most common cancer in incidence and mortality in the United States. In spite of current screening strategies 1 out of 5 patients still presents with metastatic disease. During the last 10-15 years there has been significant increase in the availability of chemotherapy options for this disease. The recent introduction of molecular markers to the treatment algorithm allows oncologists to tailor treatments for each particular patient. In the following article we give an overview of the landmark publications that led to our current standards and we give our view on particular situations in which the available evidence is not so helpful in making therapeutic decisions.

Original languageEnglish (US)
Pages (from-to)47-58
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Volume83
Issue number1
DOIs
StatePublished - Jul 1 2012

Keywords

  • Colorectal neoplasms
  • Neoplasm metastasis
  • Therapy

ASJC Scopus subject areas

  • Hematology
  • Oncology

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