Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling

Barth Grant, Yinhua Zhang, Marie Christine Paupard, Sharron X. Lin, David H. Hall, David Hirsh

Research output: Contribution to journalArticle

195 Citations (Scopus)

Abstract

In genetic screens for new endocytosis genes in Caenorhabditis elegans we identified RME-1, a member of a conserved class of Eps15-homology (EH)-domain proteins. Here we show that RME-1 is associated with the periphery of endocytic organelles, which is consistent with a direct role in endocytic transport. Endocytic defects in rme-1 mutants indicate that the protein is likely to have a function in endocytic recycling. Evidence from studies of mammalian RME-1 also points to a function for RME-1 in recycling, specifically in the exit of membrane proteins from recycling endosomes. These studies show a conserved function in endocytic recycling for the RME-1 family of EH proteins.

Original languageEnglish (US)
Pages (from-to)573-579
Number of pages7
JournalNature Cell Biology
Volume3
Issue number6
DOIs
StatePublished - 2001

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Endosomes
Caenorhabditis elegans
Recycling
Mutant Proteins
Endocytosis
Organelles
Membrane Proteins
Genes
Proteins
Protein Domains

ASJC Scopus subject areas

  • Cell Biology

Cite this

Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. / Grant, Barth; Zhang, Yinhua; Paupard, Marie Christine; Lin, Sharron X.; Hall, David H.; Hirsh, David.

In: Nature Cell Biology, Vol. 3, No. 6, 2001, p. 573-579.

Research output: Contribution to journalArticle

Grant, Barth ; Zhang, Yinhua ; Paupard, Marie Christine ; Lin, Sharron X. ; Hall, David H. ; Hirsh, David. / Evidence that RME-1, a conserved C. elegans EH-domain protein, functions in endocytic recycling. In: Nature Cell Biology. 2001 ; Vol. 3, No. 6. pp. 573-579.
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